Dr. Sears’ OmegaRx 2 Fish Oil – 10oz Liquid

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Dr. Sears’ OmegaRx 2 Fish Oil – 10oz Liquid

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Rated 4.23 out of 5 based on 52 customer ratings
(52 customer reviews)

OmegaRx®2 Sets the Standard in Purity, Potency and Freshness
OmegaRx 2 consists of purified oil from wild anchovies and sardines caught off the coast of Chile. With state-of-the-art manufacturing coupled with the science of Dr. Sears, OmegaRx 2 has become the leader in purity, potency, and freshness. OmegaRx 2 is a rich source of EPA and DHA, supplying one of the highest concentrations of omega-3s (75%) available in the consumer marketplace. This ensures you reap the greatest benefits from your omega-3 fish oil.

OmegaRx 2 Supports the Following Health Benefits

  • Brain Health
  • Heart Health
  • Behavior and Mood
  • Athletic Performance
  • Vision
  • Pre/Postnatal Health

Why OmegaRx 2 Should Be Your Choice for Omega-3 Fish Oil

  • Potency: Supplies 2250mg of EPA and 1125mg of DHA per serving which amounts to (1) teaspoon.
  • Freshness: Our proprietary antioxidant blend provides greater stability to protect OmegaRx 2 from oxidation. The TOTOX value, one measure of “freshness”, of each batch of OmegaRx 2 shows we have some of the freshest oil on the market to date.
  • The Ideal 2:1 Ratio of EPA to DHA: Based on the research of Dr. Sears, OmegaRx 2 supplies the ideal ratio of EPA and DHA which has been clinically shown to cover the widest range of health benefits.
  • Transparency: We think it’s important that you know the purity, potency, and freshness of OmegaRx 2 which is why we post the values of every lot of OmegaRx 2 post-production on our website.
  • Sustainability: Our suppliers have a long-term commitment to protecting the seas and currently hold a Friend of the Seas Certification (a non-profit dedicated to the conservation of the marine habitat)
  • Leadership: Dr. Sears has dedicated more than 40 years of research on the impact of diet and omega-3s on inflammation and hormonal response. His scientific contributions have helped lead the omega-3 industry in the manufacturing, purification, and stabilization of high potency and purity omega-3 products.
  • Value: OmegaRx 2 has one of the lowest cost per gram of EPA and DHA of any fish oil product on the market coupled with the highest purity standards for freshness.

Suggested Use: Take one (1) teaspoon daily. 60 servings per bottle.

OmegaRx 2 Liquid Storage: Store in freezer once open.

Are you taking enough?

Just like every individual is unique, the amount of omega-3s each individual is unique to them. To determine your optimal dose of OmegaRx 2 Fish Oil, use the Cellular Inflammation Kit to test your AA/EPA ratio and get your Cellular Inflammation Score. Your Score will tell you if you are taking enough omega-3 fish oil to maintain wellness.

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  • Science
  • Ingredients
  • Reviews (52)
  • Q&A
  • Purity Data
  • Sports Certification

Omega-3 Fatty Acids Are…

Omega-3 fatty acids are essential nutrients for human nutrition.  Initially, it was thought that the primary need for omega-3 fatty acids was to help increase membrane fluidity especially in the brain.  We now know their primary role is to resolve existing inflammation.

OmegaRx Fish Oil Contains…

The long-chain omega-3 fatty acids, EPA and DHA, are the building blocks for hormones called resolvins which are needed to resolve existing inflammation as well as accelerate the regeneration of new tissue.  To get these benefits, you need adequate levels of omega-3 fatty acids in the blood.

OmegaRx Purity Data…

  • PCB testing posted for every lot of OmegaRx produced
  • Fatty acid analysis posted for every lot produced
  • Rancidity Score (TOTOX) posted for every lot produced

The Best Way to Determine Your Dose Is…

The Cellular Inflammation Test can determine the levels of omega-3 fatty acids in the blood required for optimal resolution of inflammation.  The higher the score of this unique blood test, the more your body is impacted by diet-induced inflammation.

You Need to Reduce Inflammation Because…

Diet-induced inflammation is one of the primary reasons why we gain weight, develop chronic disease, and age at a faster rate.  The ideal Cellular Inflammation Score is between 1.5 and 3.  For comparison, the average American has a Cellular Inflammation Score of 19 indicating a deficiency of EPA and DHA among Americans. This deficiency results in higher levels of cellular inflammation and chronic disease.

OmegaRx 2, 10oz Liquid Supplement Facts

52 reviews for Dr. Sears’ OmegaRx 2 Fish Oil – 10oz Liquid

  1. Rated 5 out of 5

    Randy Brown

    Long time Zone liquid fish oil user here. I like the new RX2 version. No problems with the taste or the results I get from using it. Even the pouring problem is a little better, either that or I’ve gotten better at not spilling. Still, in a perfect world they would put a better pouring spout in. One example of a fish oil pouring spout that works well comes from a competing fish oil product made by Carlson labs I think. Their fish oil quality doesn’t compare to Zone fish oil, of course, but they sure did nail the pouring spout thing. lol

  2. Rated 2 out of 5

    Dorothy (verified owner)

    I am having a very difficult time taking this liquid oil because of the taste. I want to continue, but may have to return it. The taste to me is like spoiled fish and my stomach wants no part of it.

    • Dr. Sears

      In our first production run of the new OmegaRx2 liquid, we had reduced the level of our standard flavor. As a result of preliminary feedback, we have restored it to its original flavor level in subsequent runs, while maintaining the same superior concentration that is 25% stronger than before.

  3. Rated 5 out of 5

    LDucrot (verified owner)

    This is a superior product. We will continue to purchase it. This is the highest quality fish oil supplement we’ve bought. And, the taste has improved a lot since we first tried it years ago. Delivery is slow.

  4. Rated 5 out of 5


    I have been taking the fish oil for 30 days now & really like the results. The taste & smell are really minimal. This will be a regular part of my daily vitamin intake from now on. Thank you Dr. Sears for another great product.

  5. Rated 4 out of 5

    Jesus Velazquez (verified owner)

    I have bought a bottle of omegarx 2 for my kids, they are fine with the flavor and as a parent we are satisfied with this product.

    The only thing I don’t like is that it spills a little bit of product each time you use it. For a 80 dlls bottle you expect to not waste any amount of product.

  6. Rated 5 out of 5

    Walter Bonilla (verified owner)

    What a great improvement in strength, taste, and after all wellness, I use to mix it with my smoothies, and let me tell you that it is close to impossible to determine it is present. Highly recommended product. Cheer from Costa Rica.

  7. Rated 1 out of 5

    Cindy (verified owner)

    Have used fish oil from Dr. Sears for 14 years but thought I’d try the liquid after reading the reviews. Unfortunately, the fish oil odor was so strong I could not tolerate it and was not able to swallow it. I will return the liquid and reorder the capsules.

  8. Rated 2 out of 5

    Sarah Caldwell (verified owner)

    I liked that it was stronger , but I am sorry but I am unable to use the RX2 , the awful fish taste lingers horribly in my mouth and I have to take a mouth freshener after to try to get rid of It and make sure others can’t smell it . Also the oil seems to get everywhere and taints everything it comes in contact with . I put on a vest while at home only to discover a terrible fish oil smell to it . I must have dripped a drop into it when taking a spoonful. I will have to go back to capsules , much more user friendly .

  9. Rated 5 out of 5

    John Harbert (verified owner)

    Very minimal fish smell and taste.

  10. Rated 5 out of 5

    Casey H.

    Going from Omega Rx to Omega Rx2 liquid, I definitely can feel an improvement in terms of calmness and focus. I do not concur with the reviews that state there is a fishy taste. Quite the opposite, the taste is virtually non-existent and even better than Omega Rx.

  11. Rated 3 out of 5


    I concur with the reviews that mentioned the strong fishy smell and taste. Purity standards did not remove all “off-flavors”. I like the extra omega 3’s

  12. Rated 3 out of 5


    Our family has enjoyed many benefits of Omega RX for the past several years, however the NEW Zone Omega Rx2 product taste extremely fishy and we have not been able to tolerate the taste or smell. We have now tried two bottles of Omega Rx2; both times a strong offensive fishy smell was released when the cap was removed and the taste was repulsive. The above stated concerns were never an issue when taking Omega Rx over the past several years. We are now awaiting a refund.

  13. Rated 5 out of 5


    Omega Rx changed my life in so many ways, but after taking Omega Rx2, I feel a whole different appreciation of what Dr. Sears has accomplished this time with the improvements, literally. Of course, I have no pain but I have a felling of calmness and emotional stability like never before. I am definitely burning more fat also. My workouts are yielding more positive results. Although, most impressionable is the way my skin feels. It is remarkably soft and youthful. I absolutely look younger. When I look in the mirror I stare at what I think are a reversal of aging. Can this be? I don’t know, but the proof is in the pudding, or fish oil! The last incredible trait is there is no fishy taste. Even my wife and son can take it straight from the bottle in a spoon without hesitation.

  14. Rated 4 out of 5

    Carol Brydge

    We have been zoners for over 15 years and have taken the regular liquid fish oil and then later in years the tabs. We just received the new RX2 fish oil yesterday and took our first tsp dose this a.m. I have continually burped up the taste of the fish oil and was very much surprised because I have not experienced that with the other liquid or tabs. Is this the norm? Excited for this to come out in tabs (for convenience).

  15. Rated 5 out of 5


    Wow, all I have to say going from Omega Rx, which was supposed to be the purist and most potent fish oil in the world, to the new kid on the block Omega Rx 2 is WOW. You can actually feel the difference. Barry Sears does it again!

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Which Zone Omega-3 is right for you?

OmegaRx 2 Capsules Delivers Dr. Sears’ recommended amount of fish oil in one dosage of four convenient capsules with 25% stronger concentration than before, and 18x greater purity than international standards.
OmegaRx 2 Microcapsules Identical concentration and purity as OmegaRx 2 capsules, but half the size, with the same quantity of servings per bottle.
OmegaRx 2 Sport Capsules Identical purity as OmegaRx 2 capsules, but higher EPA content to help athletes with performance. Also contains GLA and toasted sesame oil to enhance the effect of EPA and DHA on muscle recovery.
OmegaRx 2 Liquid Identical concentration and purity as OmegaRx 2 capsules, but designed for people who prefer a liquid fish oil. Liquid may also be easier to swallow for children.

Why do you need Omega-3 fatty acids?

Omega-3 fatty acids are the dietary building blocks to make powerful anti-inflammatory hormones. Without adequate levels of omega-3 fatty acids in the diet, cellular inflammation increases. Furthermore, they are critical for brain function. That’s why your grandmother told you that fish was brain food. Dr. Sears recommends at least 2.5 grams of EPA and DHA on a daily basis.

Your fatty acids are now even easier to get with OmegaRx2.

Why not just eat more fish?

To get the 2.5 grams of EPA & DHA omega-3 fatty acids Dr. Sears recommends, you would have to consume either (a) 7 pounds of lobster per day, or (b) 2 pounds of tuna fish per day, or (c) one-quarter of a pound of farm-raised salmon per day. Unfortunately, these sources are either too expensive (lobster) or have high levels of toxins (tuna and farm-raised salmon). This is why ultra-refined OmegaRx 2 is your best choice to get the 2.5 grams of omega-3 fatty acids for brain health and the reduction of cellular inflammation throughout your body at the lowest possible cost. Just 1 serving daily of OmegaRx 2 provides you with more than the recommended 2.5 grams of EPA & DHA omega-3 fatty acids.

What are the primary toxins found in Omega-3 fatty acids?

The primary toxins found in crude fish oil are mercury and PCBs. The mercury is easily removed since it binds to the protein and is easily separated in the initial purification. PCBs are extremely difficult to remove. Thus, the levels of PCBs in a fish-oil product are the true test of product purity. Dr. Sears makes PCB removal the #1 priority in his products. You can see in the following graph how his standards compare to others in the fish-oil industry.


Purity counts when choosing Omega-3 fatty acids.

The OmegaRx® brand is your guarantee of purity and potency. Purity comes from maintaining the lowest levels of PCBs possible in a fish-oil product. It makes no sense to purchase any fish oil that is not extremely low in PCBs since once they enter your body, they are not coming out. Potency is based on the actual amount of EPA and DHA in the oil. Your best purchase decision is when both are optimized.

What You Need To Know About Fish Oil Purity.

Although none of the marketing companies of the three primary brands (OmegaRx, Ultimate Omega, and Lovaza) of omega-3 products actually makes its own fish oil products, companies do set standards for raw materials they use for those products they sell. The more you know about these standards, the better the product choice you can make for yourself. All omega-3 fatty-acid concentrate products come from the same source, anchovies and sardines off the coasts of Peru and Chile. What separates the quality of fish oil are the purity and potency of the final products that can be quantified by the following tests.

PCB Levels

All omega-3 fatty acid products derived from fish oil will contain PCBs. To state otherwise is simply false. The question is the levels of PCBs in the finished product. The lower the levels of PCBs in a product, the higher the purity. Unlike other brands, Zone Labs has the strictest standards in the industry for the omega-3 products it uses. The international standard for the upper limit of PCBs is 90 parts per billion (ppb). That is fine for a health- food-grade product, but not for a professional grade. At Zone Labs our upper limit for PCBs is 5 ppb, which is 18 times more rigid than commonly used international standards. However, PCB levels will vary from lot to lot. This is why Zone Labs is the only company of the three major brands that posts the levels of PCBs on each lot of its omega-3 products on its Website for all to see. Testing for PCBs is expensive, but it is your guarantee of our commitment to product excellence and purity.

Totox Levels

Omega-3 concentrates are very prone to oxidation. Even after they are bottled or put into soft gelatin capsules, oxidation of the omega-3 fatty acids will continue. The World Health Organization (WHO) has developed strict standards to determine whether or not any edible oil is rancid and, therefore, whether it is suitable for human consumption. That standard is based on Total Oxidation (Totox) levels in the product actually being used. This is a rigid standard that governs all edible oil trading in the world. Since omega-3 fatty acid are exceptionally prone to oxidation, Zone Labs is the only company that posts the Totox levels on the finished product (not the raw materials) for every lot of omega-3 fatty acid product we make.

Fatty-Acid Levels

Like PCB and Totox levels, the levels of the omega-3 fatty acids EPA and DHA are key to your ability to reduce diet-induced inflammation. That’s why Zone Labs is the only company to post the levels of EPA and DHA in every lot of omega-3 products we sell to ensure product consistency. More importantly, we also offer a fatty-acid testing service through Zone Diagnostics (www.zonediagnostics.com) that allows you to determine the actual amount of omega-3 fatty acids you require to help manage your levels of diet-induced inflammation.

Commitment to Ongoing Clinical Research

This means actually doing the research and publishing the results, not just supplying products. Zone Labs is the only company that sets aside a percentage of its product sales for continuing clinical research by the non-profit Inflammation Research Foundation. No other company has such a commitment to omega-3 fatty- acid clinical research. Zone Labs is also the only company headed by a leading medical researcher in the area of omega-3 fatty-acids.

Omega-3 Fatty Acids Are Only a Part of an Overall Anti-inflammatory Nutrition Program

The management of diet-induced inflammation requires the appropriate orchestration of the high-purity omega-3 fatty acids, adequate levels of polyphenols to protect the omega-3 fatty acids from oxidation in the body, and maintaining an anti-inflammatory diet to prevent the build-up of diet-induced inflammation. Zone Labs is the only company that offers a complete anti-inflammatory nutrition program for you. That’s why Zone Labs is the leader in anti-inflammation nutrition through our commitment to Evidence-Based Wellness®.

How do you know if you are taking enough OmegaRx® to make a difference?

Even taking OmegaRx® 2 will not make a significant difference unless you are taking enough. That’s why we say “test, don’t guess”. Using our Cellular Inflammation Test Kit, you can determine if you are taking the right levels OmegaRx® 2 that you need to reduce your levels of cellular inflammation.

Purity Counts when choosing Omega-3 Fatty Acids

We test every lot of finished product and post the results of every report because our consumers deserve to know what they’re taking. There might be 5-star fish oils, but there is only one 6-star: that’s OmegaRx. To have Dr. Sears’ name on every bottle, it has to meet his strict standards for concentration, purity and stability. See how our fish oils measure up.

Independent Third-Party Testing Reports

Sports Certified
OmegaRx 2 Liquid has been tested and successfully cleared by LGC Science (Lexington, KY) for the wide range of substances banned by the World Anti-Doping Agency (WADA). With that confirmation OmegaRx 2 Liquid is free of banned substances, including steroids, stimulants, diuretics, masking agents, and more, OmegaRx 2 Liquid is more appropriate for elite athletes than ever.

OmegaRx 2 Liquid’s clean bill of health not only speaks to its purity and safety, but also gives strong assurance to elite and professional athletes that OmegaRx 2 Liquid has been cleared for use before, during, and after competitive and sanctioned events.

LGC’s testing method identifies 160 core illicit substances that have been identified on the WADA Prohibited List or by other professional sports organizations, including the NFL, MLB, NBA, and more. Its testing capability is able to detect banned substance contaminants at levels of just 10 parts per billion (10 ng/g) or less.

Why Sports Certification Is Important

Research has shown that some supplement products have been found to be contaminated with low levels of substances that are prohibited by WADA (the World Anti-Doping Agency) and other sporting bodies. As a result, many professional athletes and the teams they play for require additional testing to provide confidence. Such additional testing also aims to provide athletes with an effective risk management service so that they can choose products that have undergone additional quality control testing as required in elite sports.

Zone Labs works with LGC to undertake such additional testing. LGC is one of the world’s leading sports doping control laboratories. Although LGC has been testing supplements since 2002, it became clear that there was a need for a comprehensive certification program, which tested products for banned substances.

Just as Zone Labs uses the leading laboratories in the world to test for levels of EPA and DHA, rancidity and PCBs to externally validate our omega-3 fatty acid products, we are now working with LGC to provide this additional testing of banned substances to our omega-3 fatty acid products that are used by top professional sports team throughout the world.

Who is LGC?

LGC is a world-renowned sports doping control and research laboratory, with over 50 years of expertise in anti-doping in sport. LGC has published over 300 scientific papers on methods for detection of trace levels of substances that are prohibited in sports and has over 450 man-years of research into doping control.

LGC has been testing supplements and ingredients on behalf of reputable manufacturers and suppliers for over 10 years. It has tested tens of thousands of samples during this time and has also carried out a number of research studies to explore the prevalence of contamination with prohibited substances in products and ingredients. LGC’s research into supplements and contamination also includes several administration studies to investigate the levels of prohibited substances that could cause an athlete to fail a doping test. These have been published in peer reviewed scientific journals.

LGC’s testing capability for supplements and ingredients includes the analysis of over 146 substances that are considered prohibited in sport and substances that pose a threat in respect to product contamination. These substances include drugs of abuse, anabolic agents, stimulants, beta-2-agonists, masking agents, etc.

As a doping control laboratory, LGC works directly with sports authorities, national anti-doping organizations, and national governing bodies worldwide. Providing advice and expert support, LGC is able to represent the views of partners and assist in the shaping of future regulation.

Is LGC a WADA (World Anti-Doping Agency) accredited lab?

LGC was only the 34th laboratory in the world to be accredited by WADA/IOC in 2004. WADA prohibits any of its accredited labs from providing commercial testing services to supplement companies. LGC voluntarily withdrew its WADA accreditation in 2007, ensuring that a high integrity testing service could be provided to address the issues of quality assurance within the supplement industry.

Their extensive experience as a sport anti-doping laboratory provides them with a unique understanding of the sports regulatory environment from a laboratory perspective.

Does LGC test for everything on the WADA Prohibited List?

The WADA Prohibited List is specifically designed for urine analysis and refers to substances found in urine (i.e. after the drug has passed through the body). The body may metabolize a banned drug to other compounds as it passes through the body.

Not all of the substances on the WADA prohibited list are able to be present in a supplement product.

Additionally, the WADA list of prohibited substances is not definitive. By necessity the list identifies classes of prohibited substances, such as anabolic agents and related substances and prohibited methods only, rather than publishing a full list of substances. When analyzing a supplement product for contaminants the Prohibited List is unable to act as a checklist for all prohibited substances against which products should be screened — supplement analysis cannot guard against contamination using untried, untested and unknown designer drugs.

Although it is not possible to test for all substances on the WADA list, LGC’s experience in testing over 50,000 samples and its’ close relationship with the WADA community, it has been possible to identify a list that will maintain product integrity.

Which substances does LGC screen for?

LGC’s testing capability for supplements/ingredients includes the analysis of over 160 substances that are considered prohibited in sport and substances that pose a threat in respect of product contamination. These substances include drugs of abuse, anabolic agents, stimulants, beta-2-agonists, masking agents, etc.

LGC screens for over 160 substances listed on the WADA and other prohibited substances lists. These include the following:

Steroids tested:

  • 1,4-androstadiene-3,17-dione
  • 4-androstene-3,17-dione and/or 5(6)-androstene-3,17-dione
  • 4-androstene-3β,17β-diol
  • 5α-androstane-3β,17β-diol
  • 5(6)-androstene-3β,17β-diol
  • 5α-androstane-3,17-dione
  • Dehydroepiandrosterone (DHEA)
  • 4-estrene-3,17-dione (19-nor-4-androstene-3,17-dione) and/or 5(10)-estrene-3,17-dione (19-nor-5(10)-androstene-3,17-dione) and/or 5(6)-estrene
  • 3,17-dione (19-nor-5(6)-androstene-3,17-dione)
  • 4-estrene-3β,17β-diol (19-nor-4-androstene-3β,17β-diol) and/or 5(10)-estrene-3β,17β-diol (19-nor-5(10)-androstene-3β,17β-diol)
  • Nandrolone (19-nor-4-androstene-17β-hydroxy-3-one)
  • Testosterone (3-chlorophenyl)piperazine 100 ng/g –

Other drugs tested:

  • Acebutolol
  • Alfentanil
  • Alprenolol
  • Amiphenazole
  • Amphetamine
  • Atenolol
  • Bambuterol
  • Benzoylecgonine
  • Benzphetamine Benzylpiperazine
  • Bisoprolol
  • Bumetanide
  • Bunitrolol
  • Bupranolol
  • Buprenorphine
  • Bupropion
  • Butofinolol
  • Canrenone
  • Carazolol
  • Carfentanil
  • Carphedone
  • Carteolol
  • Cathine (Norpseudoephedrine)
  • Celiprolol
  • Chlorphentermine
  • Cimaterol
  • Clenbuterol
  • Clomifene
  • Clopamide
  • Clobenzorex
  • Clorprenaline
  • Cocaine
  • Croethamide
  • Cyclopentamine
  • Cyproheptadine
  • Dextromoramide
  • Diamorphine
  • Diethylpropion
  • Dipipanone
  • Diprenorphine
  • Doxapram
  • Ephedrine / Pseudoephedrine
  • Esmolol
  • Etamivan
  • Fenbutrazate
  • Fencamfamine
  • Fenfluramine
  • Fenoterol
  • Fenozolone
  • Fentanyl
  • Fluorophenethylamine
  • Fluoxetine
  • Fluvoxamine
  • Formoterol
  • Gestrinone
  • Heptaminol
  • HMMA
  • Indapamide
  • Isometheptene
  • Labetolol
  • Levophacetoperane
  • Mabuterol
  • MDA
  • MDMA (ecstasy)
  • Mefenorex
  • Mefruside
  • Mephentermine
  • Methadone
  • Methamphetamine
  • Methoxyphenylpiperazine
  • Methylephedrine
  • Methylhexanamine (1,3-dimethylpentylamine)
  • Methylphenidate
  • Methyltrienolone
  • Metoprolol
  • Modafinil
  • Moprolol
  • Nadolol
  • Nadoxolol
  • Nalbuphine
  • Nalorphine
  • Naloxone
  • Naltrexone
  • Nikethamide
  • Oripavine
  • Oxprenolol 100
  • Oxycodone
  • Oxymetazoline
  • Pemoline
  • Penbutolol
  • Pentazocine
  • Pentoxyverine
  • Pethidine
  • Phendimetrazine
  • Phenmetrazine
  • Phentermine
  • Pindolol
  • Pirbuterol
  • Piretanide
  • Polythiazide
  • Practolol
  • Probenecid
  • Prolintane
  • Propranolol
  • Prothipendyl
  • Quinethazone
  • Ritodrine
  • Salbutamol
  • Salmeterol
  • Selegiline
  • Sibutramine
  • Sildenafil
  • Sotalol
  • Spironolactone
  • Stanozolol
  • Strychnine
  • Tamoxifen
  • Terbutaline
  • Tetrahydrogestrinone (THG)
  • Timolol
  • Torasemide
  • Toremifene
  • Trenbolone
  • Trifluoromethylphenylpiperazine
  • Tripamide
  • Tuaminoheptane
  • Tulobuterol
  • Xylomatazoline

What is the detection levels that supplements should be tested at?

The labs that are accredited by the World Anti-Doping Agency (WADA) to screen athletes blood and urine samples use techniques that are very sensitive — with capability to detect banned substances down to 2 nanograms per milliliter (ng/ml) of urine (i.e. 2 parts of substance in 1,000,000,000 parts of urine).

Doses (total intake) of low levels of banned substance (in the microgram range) can generate such levels in an athlete’s urine. As a result, supplements need to be tested for the presence of banned substances at sensitivity levels in the nanogram per gram or nanogram per milliliter range (as an athlete may ingest many tens of grams of supplement). Such low detection levels are beyond the “normal” QC requirements of pharmaceutical and food industries.

In supplements tested through LGC program, the Level of Detection is 10 ng/g for steroids and 100 ng/g for stimulants.

What are the limits of detection needed for banned substance screening in supplements?

The limits of detection at the manufacturing stage are much lower than those conventionally addressed by “standard” quality control procedures in the supplements industry. This is why a specialized lab like LGC is required.

The levels and limits of analytical detection have profound implications on supplement quality assurance program, demanding testing sensitivities that can only be met by highly specialized analytical laboratories, working to ISO 17025 standards. It is extremely uncommon for the manufacturing facilities used by supplement companies to have the capability to undertake such trace analysis, concentrating instead on the verification of label listings of specified contents. In most cases, supplement manufacturers will test products for other contaminants such as toxic substances, heavy metals, etc. and not necessarily for those substances that may give rise to a positive drug test for a professional athlete, such as nandrolone or ephedrine.

What is ISO 17025 accreditation and why is it important?

ISO 17025 is the key standard for an analytical laboratory. It provides absolute confidence that if contamination exists above the defined limit of detection, then it will be identified and called “positive”. Laboratories that do not meet this standard may call a “negative” simply because they are unable to find the contamination, NOT because it is absent. Their techniques may be wholly inadequate. Analysis is of no value unless it meets the exacting requirements of the various regulating bodies.

Results are therefore dependable, and will withstand scrutiny in court, in any jurisdiction around the world.

Is there a link between WADA testing and ISO 17025?

WADA screening is specifically designed for urine and blood analysis. There is no such thing as a ‘WADA test’ for anything else. However, WADA testing for urine/blood is carried out to ISO 17025 standards. ISO 17025 is an international analytical capability standard – any tests that are accredited to this standard have been developed and validated in line with international requirements and are regulated by external authorities.

LGC is a WADA-experienced lab that performs testing of supplements to the same international analytical standard (ISO 17025) that WADA urine/blood testing is carried out to.