New Breakthroughs in Treating Diabetes

Dr. Sears' Blog: New Breakthroughs in Treating Diabetes

I had the opportunity to read a fascinating little article in the July issue of Diabetes Care (1). What was interesting about this article is that one of the primary authors is a leading academic proponent for the use of drugs to treat obesity and diabetes.

In particular, this research asked the simple question: Would eating protein before eating carbohydrates in a meal have any impact on blood sugar and insulin responses in type 2 diabetic patients? To study that question required a very simple experiment. Researchers gave the diabetic patients the same breakfast at two different times, one time eating the carbohydrates first and the second time eating the protein first. The other interesting thing was the breakfast was pretty close to a Zone breakfast in that the composition of the meal was 35% protein, 43% carbohydrate, and 22% fat. Of course, it contained too many calories (628 calories vs. my recommended less than 400), but that was a detail.

What they found was that by eating the protein first followed by the carbohydrates, both the blood glucose and insulin increases in diabetic patients were dramatically reduced by 74% and 49% respectively during the next two-hour period. So what did the authors think of their results? They wrote “the magnitude of the effect of food order on glucose levels is comparable to that observed with pharmacological agents.” That is a pretty strong statement coming from one of the chief academic spokespersons for the diabetic drug industry.

But could they have achieved even better results? Probably by reducing the protein content of the breakfast from 58 g to 30 grams, reducing the carbohydrate content from 68 grams to 40 grams and reducing the fat content from 16 grams to 13 grams. This would have decreased the calorie intake from 628 calories to 397 calories. Not surprisingly, that would result in a macronutrient composition of 40% carbohydrates, 30% protein, and 30% fat. And since you have lower levels of carbohydrates and calories, the decreases in glucose and insulin would have been even greater. In fact, that was demonstrated by Harvard Medical School in 1999 (2).

As I was reading this article, I thought something seemed very familiar about this remarkable new medical breakthrough in controlling glucose levels in diabetics simply by eating protein first before consuming carbohydrates. The reason it sounded so familiar to me is because I wrote about it in 1997 in my book Mastering the Zone (3). In particular, it was Helpful Hint #13 on page 56. If Mastering the Zone had not been a New York Times bestseller with more than one million copies sold, I might understand why it took nearly 20 years for the diabetic establishment to understand how a simple dietary change of eating adequate protein first before eating carbohydrates would be equivalent to any drug. Unfortunately, with more than one million copies of Mastering the Zone in circulation, it is hard to understand why it took so long to understand that food order (if it is a Zone meal) is more powerful than a drug. Do you think it might be the money?


  1. Shukla AP, IIiescu RG, Thomas CE, and Aronne LJ. “Food order has a significant impact on postprandial glucose and insulin levels.” Diabetes Care 38:e98-e99 (2015).
  2. Ludwig DS, Majzoub JA, Al-Zahrani A, Dallal GE, Blanco I, and Roberts SB. “High-glycemic-index foods, overeating, and obesity.” Pediatrics 103:e26 (1999).
  3. Sears B. Mastering the Zone. Regan Books. New York, NY (1997).

Tags: ,

About Dr. Barry Sears

Dr. Barry Sears is a leading authority on the impact of the diet on hormonal response, genetic expression, and inflammation. A former research scientist at the Boston University School of Medicine and the Massachusetts Institute of Technology, Dr. Sears has dedicated his research efforts over the past 45 years to the study of lipids. He has published 40 scientific articles and holds 14 U.S. patents in the areas of intravenous drug delivery systems and hormonal regulation for the treatment of cardiovascular disease. He has also written 14 books, including the New York Times #1 best-seller, The Zone, which have sold more than 6 million copies in the U.S. and have been translated into 22 different languages.


  1. jessical

    My daughter suffered from a terrible tinnitus for more than 23 years which started after she turned 5 we all thought it will end but got even worse as days went by. We tried all several treatments and therapy prescribed by various doctors we met but to no avail, she lost total concentration and screamed most times. She usually tells me she hears hissing and ringing noises. This were steady noise that disrupted her entire life, even at night she screams even more because the sounds become louder because everywhere is quiet and she slept less because of this.It was during a casual conversation with a friend that i learned about dr Williams herbal medicine I was able to contact him on his email address. and give him all the necessary information that he needed,few day later he sent me the herbal portion and his medicine was able to restore her back to normal and she is very okay now without any side effects whatsoever. If you have Tinnitus, do not hesitate to contact him on for advice and for his product. I hope this also helps someone out there.

  2. KATE

    Is my pleasure to comment on this site and i thank the admin of this site for his/her great work so far. I really don’t know how to thank DR GEORGE for helping me get cured for over 20 year of suffering from a terrible tinnitus, my tinnitus started when i turns 10 we all thought is going to end one day but even get worse as days went by,i have tried all western drugs prescribed by doctors but to no avail i lost total concentration, even at night i screams even more because the sounds become louder because everywhere is quiet. i came across DR GEORGE contact through a headline news on internet about how DR GEORGE help a woman to get cured of his tinnitus and so many other with similar ear problem ,i contacted him and he told me how to get his herb,few day later he sent me the herbal portion which i take every morning for 21 days, and his medicine was able to restore me back to normal and now am very okay without any side effects whatsoever If you have Tinnitus, you can contact him on his email address for help.

  3. رژیم غذایی

    Mr hossein fathi is a Doctor with over twenty years experience in assessing the nutritional needs of patients; communicating the appropriate nutritional information to other members of the health care team; and implementing nutritional care plans.

  4. Fred Greg

    All thanks to Dr Sunshine, I am here to share a good testimony of my self on how i came in contact with a real herbalist who helped me. i appreciate everyone for taken their precious time to read my testimony, 6 months ago i was diagnosed of Diabetes, this means that 6months ago i was Diabetes positive when i told one of my good friend about this, she sympathized with me and then she said that she was going to help me out, she told me that we should do some research on the internet, we came across Dr Sunshine and my friend said that she has come across a lot about him and said that he is a real herbalist remedy to all illness, i was really surprised on this and confused as well, I was so speechless and quickly i contact him to help me and he prepared some herbs for me and send it across to me and he told me the way i was going to be taken the medicine which i did, and in the next 2 weeks i went to the hospital and they said that i am now Amyotrophic Lateral Sclerosis negative, i am very happy about this, when i contacted Dr Sunshine again to tell him the good result , i asked him how he was able to help me, and he said that he was gifted with it that he can cure illness like. call Dr Sunshine: +2349051208634 or email him via

  5. Michelle

    I so agree with you, Dr. Sears. It is the money – follow the money trail. Thank you for putting this information out there to help so many.


Leave a Reply

Your email address will not be published. Required fields are marked *