Obesity is an inflammatory condition. With time that inflammation spreads to drive tumor development in other organs. So even if you lose the excess body fat, the inflammation in other tissues is still potentially ongoing.
Although there is an indication that the genes that predispose obesity are also those that defend body fat during exercise, it only means that you have to put even more emphasis on the diet to reduce excess fat.
Ironically the dietary guidelines of the Joslin Diabetes Center at Harvard Medical School for treating diabetes is essentially the Zone Diet. For Mike Huckabee, his decision to “eat lean meats and plenty of fruits and vegetables” is the Zone Diet. Maybe that’s why he lost 100 pounds without becoming dumb or angry.
The cause for increased cholesterol production is increased insulin that activates the key enzyme of cholesterol biosynthesis in the liver. Reduce insulin levels, you will reduce cholesterol levels.
For those women with the genetic predisposition to gain weight from exercise, the answer is not more exercise but greater satiety induced by an anti-inflammatory diet.
This an association study, not a causal study, but it should be noted that taking into account BMI, then diet soda had no effect on the development of diabetes. That is a little different than the title of the story would suggest.
As I explained in my book Toxic Fat published in 2008, your best protection against the lipotoxicity that drives type 2 diabetes are healthy fat cells to prevent the excess release of stored fat into the blood to cause insulin resistance and ultimately type 2 diabetes.
Severely obese women are usually obese when they are pregnant as well as being deficient in omega-3 fatty acids. This leads to epigenetic changes can easily manifest themselves in ADHD if the child is also omega-3 fatty acid deficient during the post-natal period.
It would be interesting to see if the women lingering concussions had a higher AA/EPA ratio that the men. The higher AA/EPA ratio in the blood would be indicative of greater neuroinflammation in the brain.
It makes more sense to focus on raising omega-3 fatty-acid levels to treat hyperactivity. Unlike food coloring additives, the data on low omega-3 fatty-acid levels in hyperactive children is robust.