Dr. Barry Sears Dr. Sears Comments: - April 2, 2015

I have had the chance to read the paper in detail.  Very sloppy work in defining the fish oil used and ignoring the limited lifetime 16:4 n-3 as a degradation product.  What the author of Time article failed to mentioned is that in clinical studies when patients were given the same cancer drug used in the mouse study as well as additional omega-3 fatty acids, the survival rate of those getting the drug and omega-3 fatty acids was greater than those getting only the drug.  A very inconvenient fact.

 

Dr. Barry Sears Dr. Sears Comments: - April 1, 2015

The best marker that the brain is aging prematurely is an elevated AA/EPA ratio as it indicates ongoing neuroinflammation.

Dr. Barry Sears Dr. Sears Comments: - April 1, 2015

Part of the problem with equivocal studies on fish oil studies are their lack of precision.  The goal of fish oil is to reduce AA/EPA ratio to the levels of the Japanese, and for Americans that will require consuming about 5-7.5 grams of EPA and DHA per day.  Once the AA/EPA ratio is less than 3 and closer to 1.5, the more dramatic are the results because you are now activating the resolution process that turns off excess inflammation.

 

Dr. Barry Sears Dr. Sears Comments: - April 1, 2015

CD36 is only one of many fatty-acid-sensing proteins in the GI tract and the rest of the body (especially the hypothalamus that controls appetite).  The underlying cause maybe increased inflammation that is disrupting the information flow from the fatty acid receptor to the hypothalamus resulting in greater appetite.

 

Dr. Barry Sears Dr. Sears Comments: - April 1, 2015

A lot of old news is recycled in this article.  Finding a drug cure for obesity will be just as likely as finding a drug cure for cancer.  If you want a way to manage both diseases, then try maintaining an anti-inflammatory lifestyle for a lifetime.

 

Dr. Barry Sears Dr. Sears Comments: - March 31, 2015

One of the benefits of high-dose fish oil for Parkinson’s patients is its ability to increase dopamine levels.

 

Dr. Barry Sears Dr. Sears Comments: - March 31, 2015

It is very hard to take a high-polyphenol olive oil if there is no labeling on the bottle.  Unfortunately, the really good olive oil never leaves Italy to make it to America.  You also know that by its superior taste.

 

Dr. Barry Sears Dr. Sears Comments: - March 31, 2015

Good list but wrong order.  Start with the fish (and in particularly fatty fish) followed by the blueberries.  The clinical data on the rest is far weaker.

 

 

Dr. Barry Sears Dr. Sears Comments: - March 30, 2015

I believe that published data would strongly suggest not taking statins for any type of MS.  This is why cardiologists love statins and neurologists hate them as the brain requires adequate levels of cholesterol for optimal function.

 

 

Dr. Barry Sears Dr. Sears Comments: - March 27, 2015

Unfortunately, obesity is a disease caused primarily by pro-inflammatory diets.  The appearance of extra weight only occurs after the hypothalamus is inflamed by the diet thus distorting the complex satiety signals that tell us to stop eating.