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As silent inflammation becomes systemic it can lead to unhealthy joints. Dr. Sears designed Joint Support to help those with inflammation in their joints. Inflammation stems from excess Arachidonic Acid (AA, a long-chain Omega-6 fatty acid), thus increasing production of pro-inflammatory hormones called eicosanoids. Joint Support is formulated with concentrated polyphenols designed to regulate the production of pro-inflammatory eicosanoids. Three potent polyphenols work together in Joint Support to regulate downstream inflammation by inhibiting the genetic transcription factor, NF kappa B, which plays a key role in regulating inflammation. The three powerful polyphenols are concentrates from turmeric, ginger, and olives. Turmeric contains the polyphenol curcumin which regulates the activation of NF kappa B and also regulates delta-5 desaturase, an enzyme which forms AA.1,2 Ginger contains a group of phytochemicals called xanthines; these are dual inhibitors of enzymes that also make inflammatory eicosanoids from AA.3,4 Finally, hydroxytyrosol is a unique polyphenol found in olives which is an effective anti-inflammatory compound.5,6,7*
- Anti-inflammatory
- Polyphenol-rich
- Supports healthy mobility
- Pure and concentrated formula
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. |
Supplement Facts
Joint Support and the Zone Wellness Pyramid
References
Supplement Facts
Serving Size: One Tablet
Servings Per Container: 90 |
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 |
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|
Amount
Per Serving |
% Daily
Value* |
|
|
Turmeric (95% Curcumin) |
222 |
mg |
** |
|
Ginger Extract |
167 |
mg |
** |
|
Olive Extract 6% |
67 |
mg |
** |
|
|
* Percent Daily Values are based on a 2000 calorie diet.
** Daily Value Not Established. |
Other Ingredients: Microcrystalline cellulose, calcium carbonate, dicalcium phosphate, stearic acid, croscarmellose sodium, magnesium stearate, silicon dioxide, vegetable protein coating. | |
Dr. Sears’ focus on helping regulate inflammation involves a multifaceted approach called the Zone Wellness Pyramid. In order for each entity of the Zone Pyramid (Zone Diet, high dose ultra-refined EPA/DHA concentrates, polyphenols, and condition specific supplements) to effectively regulate silent inflammation, all must be used in conjunction.
Excess insulin boosts levels of AA and thus promotes the production of pro-inflammatory eicosanoids. By stabilizing insulin levels through eating more protein and low-glycemic carbohydrates, you regulate the activation of the enzyme (delta-5 desaturase) that produces AA, the building block of pro-inflammatory eicosanoids.
4 capsules per day. EPA acts as an inhibitor of the delta-5 desaturase enzyme thereby regulating the overproduction of AA. Reduction of silent inflammation requires maintaining an appropriate ratio of AA/EPA (the marker of silent inflammation) in the blood. Begin with OmegaRx, after stabilization of EPA levels in about 30 days (follow the Eicosanoid Status Report) slowly replace some capsules with EicoRx for your daily dosage. This will promote the production of “good” or anti-inflammatory eicosanoids that can have a benefit on improving joint function.
2 tablespoons (30 ml) per day. The polyphenols in SeaHealth regulate the activation of NF kappa B, the cellular gate keeper for genetic expression of pro-inflammatory mediators. These polyphenols also have antioxidants which support the structure of EPA/DHA concentrates by regulating their oxidation.
3 tablets per day. Contains a combination of polyphenol extracts, turmeric (curcumin), ginger, and olive (hydroxytyrosol) that act downstream to regulate the enzymes involved in producing pro-inflammatory eicosanoids.
1 Sears, Barry, The Anti-Inflammation Zone, HarperCollins Publishers Inc., New York, NY, 2005; p. 87-97.
2 Funk, J, et al, “Turmeric Extracts Containing Curcuminoids Prevent Experimental Rheumatoid Arthritis,” Journal of Natural Products, 2006; 69 (3):351-355.
3 Sears, Barry, The Anti-Inflammation Zone, HarperCollins Publishers Inc., New York, NY, 2005; p. 87-97.
4 Bliddal H, et al, “A randomized, placebo-controlled, cross-over study of ginger extracts and ibuprofen in osteoarthritis.” Osteoarthritis Cartilage. 2000;8:9-12.
5 Sears, Barry, The Anti-Inflammation Zone, HarperCollins Publishers Inc., New York, NY, 2005; p. 87-97.
6 Maiuri, M, et al, “Hydroxytyrosol, a phenolic compound from virgin olive oil, prevents macrophage activation.” Naunyn-Schmiedeberg’s Archives of Pharmacology, 2005; 371:457-465.
7 Martinez-Dominguez, E, et al, “Protective effect upon experimental inflammation models of a polyphenol-supplemented virgin olive oil diet.” Inflammation Research; 2001; 50(2):102-106. |
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