There will always be an ongoing debate concerning the efficacy of omega-3 ethyl esters vs. triglycerides. The omega-3 products provided by Dr. Sears are ethyl esters. .First, ethyl esters are safe despite some manufacturers misleading claims. To say that the triglyceride form is more absorbable is inaccurate. The honest comment should address the “absorption speed.” See: http://www.minami-nutrition.com/web...rption.php
There is a lot of misconception concerning EPA/DHA concentrates. Natural fish oils are generally very low in EPA and DHA. For example, only 15% of the fatty acids in cod liver oil consist of EPA and DHA. The only way to increase the potency of EPA and DHA is to convert them to ethyl esters and then distill over EPA and DHA at low temperature to increase their concentration. In the process, you also remove much of the inherent contaminants, such as dioxins and PCBs. The higher the potency of an EPA/DHA concentrate, the lower the levels of the contaminants it contains. Furthermore, it is the ethyl ester form of EPA and DHA that has been used in the vast majority of clinical trials that have demonstrated the remarkable benefits of omega-3 fatty acids as nutritional supplements. Some manufacturers try to synthetically reconvert these ethyl esters back into a triglyceride form touting it as “natural”. Nothing could be further from the truth. The reconstituted triglyceride molecule has a totally different positioning of the EPA and DHA as found in low-potency natural fish oils. More ominously, during the conversion process, some of the EPA and DHA are polymerized to make a sludge that cannot be removed from the mixture. When you are taking a product consisting of a reconstituted triglyceride, that polymerized sludge is part of your supplementation.
If you want truly pure EPA/DHA concentrates that have been clinically tested, then insist on ultra-refined ethyl esters like omega-3 products provided by Dr. Sears. They consist of a fatty acid attached to an ethyl alcohol molecule. The empirical formula of EPA ethyl ester is C22H34O2 and the empirical formula of DHA is C24H36O2. The molecular weight of EPA is 330.51 and DHA is 356.55.
Here’s a previous email response you may find of interest.
"Fish Oil, The Natural Anti-Inflammatory" (Dr. Maroon, Nordic Naturals' spokesman) states that "the ethyl ester form has been shown to be fifty times more resistant to enzymatic digestion than the triglyceride form. ...... the body absorbs the triglyceride form up to 300 percent better than the synthetic ester form" Do you know if this research used ethyl esters that had benefited from the retriglyceride process? As you’re experiencing for every Ph.D there’s always an equal and opposite Ph. D. Interesting, LOVAZA a prescription omega-3 ethyl ester medication has been clinically proven to dramatically reduce very high triglycerides in adults. Dr. Sears said., “I know Joe (Dr. Maroon) and unfortunately he’s wrong.” This debate will continue forever… was Dr. Maroon aware that there can be a 24 hr. delay in the absorption of EE.
Dr. Maroon states, " In Sweden, Denmark, Norway, and the UK, only fish oil with EPA and DHA in triglyceride form can be sold due to the stability and absorption issues". Do you know this to be true? If a triglyceride is more than 30% epa/dha this can lead to problems. Given the geographic areas mentioned, I can imagine possible political involvement in such a decision. Could be, however, Lovaza an ethyl ester, is produced in Norway. See: http://www.lovaza.com/
Are there any positive nutritional values to eating the skin of salmon and other fish? No added value. In fact some of the toxins reside in the skin. Best to consume fish for its protein value and supplement with a high quality fish oil for the omega-3’s.
Due to "oxidation", is it preferable to cook fish, meat, etc. first and eat it within a few days or store the product and cook portions as needed. Oxidation of fats occurs when cooking, more so at high heat. Have the fats in ground meat and poultry been oxidized more compared to non ground products? No Is any of this oxidation important? Relax, following the Zone, supplementing w/ OmegaRx and practicing daily meditation is more important.
I found it difficult to read the Lyon Heart Study and I read articles in med. journals regarding the study but none mentioned the AA/EPA test. The AA/EPA data is within the charts/tables. Can you site one that does? Sorry, only this link: http://www.ncbi.nlm.nih.gov/pubmed/...d_RVDocSum
Is there AA in Omega-3 supplements? Yes If so, is anyone measuring it? We do, but it is internal information that I don’t have. Dr. Sears reviews the data to be sure it falls within an acceptable range that is less than 2% of the fatty acids. The range of AA in most fish oil is around 10-12 %. I understand AA is higher in farm raised fish compared to wild - last year the Dept. of Ag reported the AA in farm raised salmon was a high as in a "hamburger". This is probably correct.
Additional information regarding Zone Labs OmegaRx.
Where does Zone Labs get its fish?
The answer to this question is important, and it’s one of the many reasons that Zone Labs’ Ultra-Refined Omega-3 Concentrates are three times fresher and contain less than 1/10th the mercury than what is allowed by both the Norwegian Medicinal Standard and the European Pharmacopoeia Standard.
Clean sources. No farmed fish. No large fish. Pristine waters.
Zone Labs starts with wild sardines and anchovies fished from cold, pristine waters off of South America where there are less environmental impurities. When the refining process is complete, Zone Labs uses a proprietary validation and testing processes to achieve an IFOS (International Fish Oil Standard) 5 star rating.
8 Step Manufacturing Process for Ultra-Pure Omega-3 Concentrates
1. Extraction of fish oil
2. Winterization – remove limited amounts of saturated fats
3. Absorption – remove heavy metals
4. Preliminary Molecular Distillation – refining "touch up" to reduce contaminants
5. Oil conversion to ethyl esters
6. Ethyl ester thermal fractionation – remove additional saturated fats
7. True Molecular Distillation – final refining to remove pcb’s and long-chain monoenes
8. Rigid Processes – proprietary validation, inspection and encapsulation methods. Independent lab verification of IFOS requirements and certified 5 star rating.
Zone Labs adheres to the International Fish Oil Standard (IFOS), and uses an independent third party laboratory to test every batch to ensure each batch receives the highest rating (5 star) before it ships.
• No company in the world runs more tests with IFOS than Zone Labs.
• Zone Labs receives a 5 out of 5 star rating for every batch it ships.
• Zone Labs tests the final bottled product to the IFOS standard, not the bulk refined fish oil before it enters the encapsulation process. The encapsulation process can introduce additional oxidation, but our proprietary encapsulation process guards against this. When you use Zone Labs’ ultra-refined omega-3 concentrates, we ensure that the product you are actually ingesting meets the IFOS quality standard. If you take a competitor’s fish oil, you should find out about its purity standard and if the finished product is actually tested.