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Adenosine Triphosphate (ATP)

This is the primary fuel used by cells to generate the biochemical reactions essential for life.

Adrenals

The glands located on the top of the kidneys that are responsible for the production of stress-related hormones, such as cortisol, DHEA, and adrenaline.

Aerobic Capacity

The body's ability to process oxygen. It is a combination of lung capacity, the size of the capillaries, the pumping action of the heart, and transfer of oxygen from red blood cells to target tissues.

Aerobic Exercise

Exercise with a low enough intensity to facilitate adequate oxygen transfer to the muscle cells so that no buildup of lactic acid is observed. This type of exercise is useful for reducing insulin levels and lowering blood glucose.

Alpha Linolenic Acid (ALA)

This is the short-chain omega-3 fatty acid commonly found in the diet. Common sources include flaxseed and soy oils. Unfortunately the metabolism of ALA into the longer-chain omega-3 fatty acids, such as EPA and DHA, is very inefficient in humans.

Amino Acids

These are the building blocks of protein. There are eight essential amino acids the body cannot make and, therefore, must be included in the foods you eat.

Anaerobic Exercise

Exercise at an intensity that exceeds the ability to supply oxygen to the muscle cells leading to the buildup of lactic acid. Anaerobic exercise stimulates the synthesis of both growth hormone and testosterone.

Anti-inflammatory medicine

The use of nutritional interventions to increase anti-inflammatory eicosanoids while simultaneously decreasing the production of pro-inflammatory eicosanoids.

Arachidonic Acid (AA)

This is the 20-carbon length long-chain omega-6 fatty acid that is the immediate precursor of many eicosanoids that increase inflammation. Egg yolks, fatty red meat, and organ meats are rich sources of arachidonic acid.

AA/DGLA Ratio

This is the marker of the balance of the precursors of pro-inflammatory to anti-inflammatory eicosanoids. The higher the AA/DGLA ratio, the less anti-inflammatory eicosanoids will be produced.

AA/EPA Ratio

The ratio is determined from levels of these long-chain omega-6 and omega-3 fatty acids in the plasma phospholipids. The AA/EPA ratio provides a precise measurement of the balance of eicosanoid precursors in a patient. The higher the AA/EPA ratio, the greater the levels of silent inflammation.

Blood Glucose

The primary source of energy for the brain. Elevated blood glucose levels cause diabetes and accelerate aging.

Calorie Restriction

The reduction of calories that maintains adequate levels of protein and essential fats while also supplying adequate amounts of micronutrients (vitamins and minerals).

Cortisol

The hormone released from the adrenal glands in response to stress or low blood glucose. Its primary mode of action in the times of stress is to shut down eicosanoid synthesis. Its synthesis in the adrenal gland requires the second messenger, cyclic AMP.

Cyclic GMP

A second messenger that begins the biological response initiated by a hormone. Cyclic GMP is the second messenger induced by nitric oxide.

Diabetes

A condition in which blood glucose is not well controlled. Type I diabetics make no insulin, whereas Type II diabetics are characterized by the overproduction of insulin, but the inability of the target cells to respond to the insulin.

Dihomo Gamma Linolenic Acid (DGLA)

This is the essential fatty acid precursor of arachidonic acid. The eicosanoids derived from DGLA have powerful anti-inflammatory properties, which are opposed to pro-inflammatory properties of eicosanoids derived from arachidonic acid (AA). Adequate inhibition of the delta-5 desaturase will increase the levels of DGLA relative to AA in individual cells.

Docosahexaenoic Acid (DHA)

This is the long-chain omega-3 fatty acid that critical for brain function. DHA is ultimately derived from EPA. DHA is found in high concentrations in neural tissues.

Eicosanoids

Eicosanoids are hormones derived from 20-carbon essential fatty acids. These fatty acids are AA, DGLA, and EPA. These hormones control inflammation. It is balance of eicosanoids that comes from long-chain omega-3 and omega-6 essential fatty acids that ultimately determines a person’s state of wellness. The 1982 Nobel Prize in Medicine was awarded for understanding the role of eicosanoids in human disease.

Eicosapentaenoic Acid (EPA)

This is the 20-carbon length long-chain omega-3 fatty acid that that inhibits the formation of arachidonic acid (AA). Fish oils are the richest source of EPA.

Essential Fatty Acids

These are fatty acids that the body can’t produce and must be part of the diet. There are two classes of essential fatty acids: omega-3 and omega-6. These differ by the positions of the double bonds within the fatty acids. This positioning determines their three-dimensional structure in space, and hence the type of eicosanoids that can be made from them.

Estrogens

A group of three steroid hormones that convey female characteristics and control fertilization. The production of estrogen is stimulated by follicle-stimulating hormone (FSH), which uses cyclic AMP as its second messenger.

Free Radical

Any molecule that contains an unpaired electron. Free radicals are unstable and will extract electrons from other biological molecules, which generates more free radicals.

Gamma Linolenic Acid (GLA)

This is the immediate metabolic product of linoleic acid. This fatty acid is found in certain foods (such as oatmeal), edible oils (such as borage oil) and also found in human breast milk. GLA is rapidly metabolized into DGLA and potentially into AA depending on the activity of the delta-5 desaturase enzyme.

Glucagon

The hormone from the pancreas that causes the release of stored carbohydrate in the liver to restore blood glucose levels. Glucagon uses the second messenger cyclic AMP to exert its biological action.

Glucose

The only simple carbohydrate that circulates in the bloodstream. Glucose is the primary fuel used by the brain. It can also be stored in the liver and muscles in a polymer form known as glycogen.

Glucose Tolerance

The ability of muscle cells and the liver to remove glucose from the bloodstream. As you age, glucose tolerance decreases.

High Density Lipoprotein (HDL)

The "good" cholesterol that helps remove cholesterol from cells. If insulin levels go up, then HDL levels go down. The lower your HDL level, the more likely you are to suffer cardiovascular complications.

Hormones

Biological compounds that communicate information at a distance. Hormones require specific receptors to begin their biological action and use second messengers to initiate the cellular process that uses that information.

Insulin

Insulin in secreted by the beta cells of the pancreas to lower blood sugar levels. The carbohydrate content of a meal primarily stimulates insulin secretion. It is essentially a storage hormone that drives macronutrients (carbohydrates, protein, and fat) into cells for immediate use or long-term storage. High levels of insulin activate the delta-5 desaturase enzyme thus increasing AA levels.

Lean Body Mass

The total body weight minus the fat mass. Lean body mass consists of water, bones, collagen, and muscle.

Linoleic Acid

This short-chain omega-6 fatty that can be converted into arachidonic acid by way of intermediates such as gamma linolenic acid (GLA) and dihomo gamma linolenic acid (DGLA). Linoleic acid is the most common dietary form of all essential fatty acids.

Macronutrient

Any food that contains calories and, therefore, can generate hormonal responses. Protein, carbohydrate, and fat are macronutrients.

Micronutrient

Vitamins and minerals that have no caloric value and little direct impact on hormonal response.

Omega-6 Fatty Acids

The type of polyunsaturated fatty acids found in protein and most seed oils. This type of fat can generate both "good" and "bad" eicosanoids.

Percentage Body Fat

This describes the percentage of your total weight that is composed of fat. The higher your percentage of body fat, the greater the likelihood of chronic disease, such as heart disease, cancer, or diabetes.

Resolvins

A new class of anti-inflammatory eicosanoids derived from EPA and DHA that is induced by conformational in the cyclo-oxygenase (COX) enzyme induced by low dose aspirin.

Triglycerides (TG)

The form of fat found in various lipoproteins in the bloodstream. High levels of triglycerides are usually indicative of high levels of insulin. The ratio of TG/HDL is a powerful indicator of insulin levels and is strongly predictive of future cardiovascular events.

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Dr. Barry Sears, PhD.Dr. Barry Sears is a leading authority on the dietary control of hormonal response. A former research scientist at the Boston University School of Medicine and the Massachusetts Institute of Technology, Dr. Sears has dedicated his research efforts over the past 30 years to the study of lipids. He holds 13 U.S. Patents in the areas of intravenous drug delivery systems and hormonal regulation for the treatment of cardiovascular disease.

A turning point in his research occurred in 1982. That year, the Nobel Prize in Medicine was awarded for discoveries of the role that specialized hormones, known as eicosanoids, play in the development of cardiovascular disease, diabetes, auto-immune diseases, and cancer. Since eicosanoids are only generated from dietary fat, Dr. Sears reasoned that one could apply intravenous drug delivery principles to nutrition in order to control these exceptionally powerful hormonal responses with laser-like precision. In essence, his approach treats food as if it were a drug.

This area of his research led to various patents in the area of hormonal control by essentially using food as an oral drug delivery system to modulate eicosanoids especially for cardiovascular, diabetic, and neurological patients.

The impact of Dr. Sears’ revolutionary work in the dietary control of hormonal response began with the publication of his landmark book, The Zone. Since its publication in June 1995, The Zone has sold more than 2,000,000 hardcover copies, and became a #1 best seller on the New York Times book list. In addition, The Zone has been translated into 22 languages indicating a worldwide response to Dr. Sears’ research. His second book, Mastering the Zone, published in 1997, also became a New York Times bestseller with hardcover sales in excess of 500,000 copies to date. His third book, Zone Perfect Meals in Minutes, published in 1997, quickly became one of the best-selling cookbooks of 1997 and an another New York Times bestseller. The Anti-Aging Zone was published in 1999 and provides the molecular insights into how the Zone Diet can reverse the aging process. The Omega Rx Zone, published in 2002, explores the molecular foundation of chronic disease and how high-dose fish oil can dramatically reverse it. His latest book The Anti-Inflammation Zone discusses how to combat silent inflammation in order to reduce the risk of cancer, heart disease, diabetes, dementia, and many other inflammatory conditions—and how to reverse these conditions if they are already present. To date more than 5 million hardcover copies of his Zone books have been sold in the United States.

His research has elevated food from more than simply a source of calories to being recognized as an exceptionally powerful drug. Because of his revolutionary research, Dr. Sears has been a frequent guest on many national programs such as 20/20, Today, Good Morning America, CBS Morning News, CNN, and MSNBC.

Dr. Sears continues his ongoing research as President of Zone Labs, a biotechnology company in Danvers, MA as well as the President of the non-profit Inflammation Research Foundation in Marblehead, MA. In addition to continuing research on the hormonal effects of food, Dr. Sears has expanded his research in developing innovative dietary approaches to treating cancer and neurological conditions, as well as his on-going work in treating cardiovascular diease and type 2 diabetes.

I have been taking the Fish Oil for over 3 years now. I am 44 playing hockey and working out. The Fish oil helps with the pain that I get from playing hockey. It greatly enhances my performance on the ice and while working out. I have noticed a big difference in my energy, attentiveness and memory. If I miss a day for whatever reason, I notice a huge difference and it feels like something is missing. Anyway that is my short little story and it comes from the heart.

– Carter B.

 

I am a nutritionist and Ph.D. doctor of health and nutrition. For Dr. Sears to figure out balancing fat, carbs and protein, is really beyond brilliant. It is a milestone in diet history. I go over people's diet/emotional journals. Mostly all the time, we discover that the fatigue, irritability, unstable emotions were due to the imbalance in their diet. Using the Zone to balance them out, helps control weight, roller coaster emotions and gives them energy. Dr. Sears is so right when he says food is medicine. He has figured out the most powerful drug combination going, called The Zone.
Best and healthy wishes,

– Elaine W., Ph.D., N.C., M.A.

 

I have a very exhausting job as a flight attendant. I read the "Omega Rx Zone" about 4 years ago and started taking the fish oil. I am 47 and have been flying for 22 years. I am very active, I run and lift weights. But combining lack of regular sleep, a physically demanding job, and irregular eating patterns this job takes a toll on the body. Since taking the fish oil, I have noticed that I do not get exhausted. I get tired, but not exhausted. I stopped taking it for a couple of months and then started taking another company's fish oil. I started getting exhausted again. I came back to Zone Labs and will continue with the fish oil for the rest of my life. I believe in the product and it makes a huge difference in my life. It makes a difference with my running as well. I also bring the bars and shakes with me on the road. It is almost impossible to eat the way I should at work. I haven't found the right secret. At least I have my Zone fish oil, bars, and shakes.

– Kathryn S.

 

I have been in the Zone, for about 1 month now. I wanted to share with you how wonderful I think this program is. I have been a personal trainer for almost 10 years and actively compete in numerous athletic activities. The Zone program has helped me to achieve a better awareness of my nutritional needs and the results I have seen are amazing! I have lost nearly 13 lbs since I have been in the Zone. I feel more mentally alert, more focused at work, have greater intensity during my training, have made significant strength gains, and just feel better over all. With that said, I would like to thank you for helping me in my quest for "super-health"!
Thank you!

– Rob Y.

 

I read 'The Zone' and as exactly as I could followed the advice for diet. I noted weight loss progress. Over six months, I lost 33 pounds. One year has passed since then. I have maintained the new weight, guided always by Zone concepts. The Zone is powerful - I have found it fantastic and I am very grateful to Dr Sears.

– Lyn S.

 

Before I stumbled across the Zone I was weighing close to two hundred pounds and I was depressed. I used to be a gymnast as a young man. I would think, "look at me now," when I looked in a mirror. The day I found 'The Zone' book, I was intrigued and as I read it the science made sense and so, I began to follow the "treatment". I began to lose weight and I was feeling way more energetic. I am forty two years old, I am very active and my weight is down to 162 lbs, 38 pounds lost on the Zone. I cycle, walk, jog, swim and I can now perform some of the more simple gymnastic skills I did twenty years ago...I literally feel like I have turned back the clock.
Thank you!

– Jack J.

 

I have been on the Zone diet for 7 years. I did not go on the diet to lose weight necessarily; but fairly quickly I lost 25 pounds, going from 190 to 165; from a 36-inch waist to a 32-inch waist. I primarily did the Zone to live healthier. My health is excellent now. I just turned 62 years old. My Zone is my eating lifestyle now; I seldom stray; and I do not miss anything. It is The Good Life.

– Curtis Y.

 

My wife's doctor told her to read "Enter the Zone" and to do the diet, so I told her I would do it with her. After only one week on the plan we went on a strenuous hike (the first of the year), and when we stopped at our favorite coffee shop on the way home I was able to get out of the car and stand upright and walk into the place without pain or stiffness. The Zone had eliminated all the inflammation that had always forced me to stumble all humped over into the coffee shop any time we skied or hiked all day.
Thank you, Doctor Sears.

– Larry C.

 

I used to have a lot of knee pain when I walked or ran. I have been taking Omega Rx for almost a year now, and rarely have any pain. I believe it is the anti-inflammation action of the oil. I feel smarter as well. Thanks for developing such a superior oil!

– Joe W.

 

Prior to following the Zone Diet, my body fat was around 15% and my weight around 153 pounds. No matter what I did, my weight and body fat did not change much. I regularly cycled 20-30 hours per week logging well over 400 miles. That had little impact on body fat or weight. Diet also seemed to have little impact on body fat or weight. Within a couple of months of following the zone diet, my weight dropped rather quickly to 142 pounds and body fat to about 8%. I still regularly cycle up to 20 hours per week (during the summer). I have also started strength training. I eat about 16 blocks per day. I take 3.6 grams of fish oil per day, along with Vitamin E, Alpha Lipoic Acid, CoQ10, and B & C vitamins. I also take GLA, which in my opinion, has significantly reduced fatigue and improved recovery times after exercise.

– Jeremy S.

All polyphenols have antioxidant properties than can be measured by their Oxygen Radical Absorption Capacity (ORAC), but not all polyphenols have anti-inflammatory properties. The polyphenols in Dr. Sears’ Zone Polyphenol Plus have been carefully chosen to have both.

Polyphenols are the phytochemicals that not only give fruits and vegetables their color, but also help regulate inflammation. In addition, polyphenols also activate the key enzyme (AMP kinase) that helps restore cellular ATP levels. Polyphenols also help regulate the activation of inducible inflammatory proteins (such as COX-2 and inflammatory cytokines).

There are more than 4,000 known polyphenols, and the richest sources are fruits and vegetables. In general, the more color a fruit or vegetable has, the richer the polyphenol content.

Why OmegaRx From Zone Labs?

Certified Purity and Proven Potency

Zone Labs’ Ultra Refined Omega-3 Concentrates are three times fresher and contain less than 1/10th the mercury than what is allowed by the Norwegian Medicinal Standard and European Pharmacopoeia Standard

Zone Labs adheres to the International Fish Oil Standard (IFOS), an independent third party validated laboratory quality standard that is more rigid than any other global standard for purity.

  • No company in the worlds runs more tests with IFOS than Zone Labs
  • Zone Labs receives a 5 out of 5 star IFOS rating for every batch it tests
Standard IFOS Standard for a 5-Star Ranking Council for Responsible Nutrition European Pharmacopeia Norwegian Medicinal Standards
Peroxide < 3.75 meg/kg 5 meg/kg 10 meg/kg 10 meg/kg
Totox Levels < 20 meg/kg 26 meg/kg NA NA
Lead < 10 ppb 10 ppb 100 ppb 100 ppb
Mercury < 10 ppb 10 ppb 100 ppb 100 ppb
Dioxans and Furans < 1 ppt 2 ppt 2 ppt 2 ppt
PCBs < 45 ppb 90 ppb NA NA

 

 

 

 

 

"IFOS – THE TOP GLOBAL PURITY STANDARD FOR OMEGA-3 FROM FISH"

Zone Labs products show no detectable lead or mercury when tested down to 10ppb, which is 10 times below the Norwegian Medicinal Standard and European Pharmacopoeia Standard limits.

Zone Labs products are three times fresher than the minimum allowed by the Norwegian Medicinal Standard and European Pharmacopoeia Standards (based on average peroxide values).

 

Zone Labs starts with only wild, small fish from pristine Chilean waters and ends with proprietary validation and testing processes to achieve an IFOS certified 5 star rating.

8-Step Manufacturing Process - Quality Assured

Testing to specification all raw materials, bulk products, packaging material and finished products – always using stringent internal standards and in-process testing.

  1. Extraction of fish oil
  2. Winterization – remove limited amounts of saturated fats
  3. Absorption – remove heavy metals
  4. Preliminary Molecular Distillation – refining “touch up” to reduce contaminants
  5. Oil conversion to ethyl esters
  6. Ethyl ester thermal fractionation – remove additional saturated fats
  7. True Molecular Distillation – final refining to remove pcb’s and long-chain monoenes
  8. Rigid Processes – proprietary validation, inspection and encapsulation methods. Independent lab verification of IFOS requirements and certified 5 star rating

 

Clean Sources

No farmed fish. No large fish. Pristine waters.

Zone Labs starts with wild sardines & anchovies fished from cold, pristine waters off of South America where there are less environmental impurities.

 

A recommended serving of Zone Labs Ultra-Refined Concentrates delivers 8 times more omega-3’s than a typical retail fish oil supplement.

Most fish oil supplements have 30% or less of the healthy omega-3s EPA and DHA, with the remaining 70% of the capsule containing unbeneficial, lesser refined fatty acids that contribute to their bad taste and gastric side effects.

 

Getting a clinically valid dose of omega-3’s is easy with Zone Labs’ Ultra-Refined Omega-3 Concentrates.

Typical Retail Dose = 300mg omega-3

Standard Zone Dose = 2400mg omega-3

 

A serving of canned tuna has 12 times less omega-3’s than
Zone Labs Ultra-Refined Omega-3 Concentrates

Commonly consumed fish and shellfish in the United States

Mercury Source: Food and Drug Administration, FDA 1900-2004, “National Marine Fisheries Service Survey of Trace Elements in the Fishery Resource". Omega-3 Level Source: American Heart Association Website.

  Mercury level
in parts per million (ppm)
Omega-3 fatty acids
(milligrams per 3-oz. serving)
Zone Omega-3 Products < 0.01 2400 (standard 4 capsule serving
Salmon (fresh, frozen) 0.014 1200
Flounder or sole 0.050 480
Pollock 0.041 450
Crab 0.060 400
Scallops 0.050 290
Shrimp ND* 290
Catfish 0.050 270
Clams ND* 250
Cod 0.095 210
Canned Tuna (light) 0.120 200
* ND: Mercury concentration below detection limit.

 

OmegaRx®

Zone Labs’ leading product. OmegaRx delivers all of the benefits of Zone Labs’ ultra-refined omega-3 concentrates.

Advantages

  • Delivers clinically proven health benefits from the omega-3 fatty acids EPA and DHA*
  • Promotes a healthy heart, healthy brain, healthy immune system, healthy circulatory system, healthy joints, healthy moods, healthy triglyceride levels and a healthy pregnancy*
  • Combats silent inflammation

 

*These statements have not been evaluated by the Food and Drug Administration.

These products are not intended to diagnose, treat, cure or prevent any disease.

 

 

 

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