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Subject: Peskin's views on Sears.........

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crumbelina User is Offline
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01/23/2004 2:54 AM
Hi ALL! Just thought you would find this amusing! It is a conversation a friend of mine had with Brian Peskin, author of Radiant Health, which was pulled from the bookstores....his answers are highlighted in blue....don't let it get to you! They have also sent me 11 pages of research showing how fish oil is dangerous and unhealthy to be taking..........can't wait to read this one...crumbelina Subject: EFA Ratios Dear Brian, I wanted to begin by saying congratulations on your day in court. I spoke with one of the women at YES and she let me know how everything turned out.[color=blue:bfb1f0256e] thanks. truth wins ......... [/color:bfb1f0256e] Recently, I was having a conversation with a couple of people who have embraced Dr. Barry Sears information on EFA's (his book). They began asking me what was in your product and what the ratio of 3 to 6 was in the oils. [color=blue:bfb1f0256e]more parent omega 6 than parent 3[/color:bfb1f0256e] [color=blue:bfb1f0256e]and NO fish oils! [/color:bfb1f0256e] I know you have changed the formula and I feel great taking it--and for me, real life results is proof. What are your thoughts on his information. He recommends taking PURIFIED fish oil and avoiding safflower, pumpkin, canola and other omega 6's because he thinks we get enough in our diet and will thow off the ratio of 3 to 6 that we need. Can they really puritfy fish oil without taking out the nutritional properties? [color=blue:bfb1f0256e]i assure you that he knows little in this area.[/color:bfb1f0256e] [color=blue:bfb1f0256e]other areas ok but NOT here --- lunatic![/color:bfb1f0256e] I am sure you are more than familiar with all of this. I would like to know how to respond to their insistance that he is right. I have called Biocytology company to get your updated science which I believe they are selling and waiting for a return call. In the mean time, I would love your feedback. [color=blue:bfb1f0256e]** it is my science [/color:bfb1f0256e]Since taking your new product, I do not have a desire to eat nuts and seeds. Are there oils or certain fats that one should avoid with the new supplement? Also, If you have this information in print somewhere, please let me know. I do have the Radiant Health Book, but I know you have updated some of that information. [color=blue:bfb1f0256e]look at XXXXXXX for the omega paper, but since you ask, here it is! my best, b[/color:bfb1f0256e]Thank you for your help as always, XXXXX XXX
crumbelina User is Offline
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01/23/2004 3:09 AM
Peskin's research on fish oil and his product: The Cure's™ EFAs, are in our opinion, the ideal way to replenish some of the essential oils (your body can't make them, they must come from food) that Mother Nature intended for us to receive on a daily basis, before the food processors ruined them. You can now "cure" the deficiency. You can consume some of the "bad stuff" (cancer-causing transfats) so long as you have a constant source of "the good stuff" (unprocessed EFA-containing oils). Many of us are overdosing on harmful transfats and not getting enough of the unprocessed oils containing the precious EFAs. The Cure's™ EFAs use organically raised and organically processed (via low temperature) seed oils. This remarkable formulation is unique and highly specialized. You can rest assured there are no fishy oils that need to be masked with other flavors. Fish have no oil glands so creating fish oil supplements essentially means you get "juiced" fish. "Juiced" fish is not the best way to get your EFAs. This is one of the reasons we don't offer fish oils. Another reason is contaminated water supplies. Fish toxins, including mercury, will magnify into higher and higher levels in these concentrated fish oils. You do NOT want this regardless of who is making the claims for concentrated fish oils. Furthermore, fish is high in derivative EFAs, not the required “parent” EFAs, like Mother Nature intended. You can do much better than that and Y.E.S. gives you the solution. Here’s how. Instead of relying on fish oils containing mainly "derivative-based" EFAs, we use expensive organic Evening Primrose oil and/or organic high linoleic Safflower oil - both excellent sources of "parent" omega 6, along with organic flax oil and organic or wildcrafted Pumpkin oil for "parent" omega 3, to obtain what we consider the ideal science-based “parent” omega 3/6 combination. There is a misconception among nutritionists that we already get plenty of omega 6 in our diets. The problem is that we get very little pure, unadulterated "parent" omega 6 oils because, to get long shelf-life, most are turned by the food processors into cancer-causing transfats or damaged in some way making them ineffective. More than 97% of our body needs at least a 4/1 ratio in favor of "parent" omega 6 over "parent" omega 3 because that is what your tissue and organs require. We bring you convenience without compromising quality or requiring refrigeration. How do we know that our formula is so great? Because thousands of people from around the world, including athletes, celebrities, and people like you and me, rave about it, including our entire staff and many of their family members, and never miss a day without it! "What makes The Cure's™ EFAs worth the price?" It REALLY Works! In our opinion, these oils are better than "liquid gold." They are in a league of their own. All the money in the world can't help your health more than these products. Unlike most commercial oil supplements, The Cure's™ EFAs are produced in small, limited quantities. The oils have no pesticides and have organic certification. We have these incredible oils produced in a pristine part of the world that we won't even disclose, because we want to keep it pure and unadulterated. After low temperature pressing, we use special capsules with low oxygen permeability to protect the precious oils so no refrigeration is required. Because of our unique formula, their effectiveness can be up to 10 times greater than oils bought in your supermarket or health store. Since no fish oils are ever used, there is no "fishy" aftertaste. And you can rest assured that you receive "parent" oils, not the dangerous overdoses of "derivatives," as found in so many commercial products that some of the world's leading scientists speak about. Now, you don't have to settle for a "Toyota Tercel" when you can have the "Rolls Royce" of oils for just a tad more! Welcome to our "family." You will notice The Cure's™ difference, and we want your testimonial when you experience it. From Peskin's website! crumbelina
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01/23/2004 5:07 AM
Apparently they are not aware that the conversion of short-chain omega-3s is very inefficicent. (1)(2) Since biological pathways evolve in reverse, the only way to explain this inefficiency is that Mother Nature intended humans to get their omega-3's in long-chain form. This is supported by the evidence that modern humans evolved near the water. (1) Virginia M. Ursin "Modification of plant lipids for human health: development of functional land-based omega-3 fatty acids" Journal of Nutrition 133:4271-4274, Dec 2003 (2) Michael J James, et al "Metabolism of stearidonic acid in human subjects: a comparison with the metabolism of other n-3 fatty acids" American Journal of Clinical Nutrition, Vol. 77, No.5, 1140-1145, May 2003
crumbelina User is Offline
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01/23/2004 5:56 AM
Just three of 11 pages, if anyone would like to read the rest just let me know! [b:f2bd272fe8]EFA SUPPLEMENT ANALYSIS[/b:f2bd272fe8] [color=red:f2bd272fe8]WARNING:Everyone is Overdosing on Omega 3[/color:f2bd272fe8] — Fish Oil Decreases Immunity! Analysis of the western diet shows a signifi cant preponderance of omega 6 compared to omega 3 —most people ’s diets consist of foods that contain approximately twelve times more omega 6 than omega 3.Physicians and nutritionists tell us that we are therefore “overdosed ” on omega 6 from our food,,while undersupplied with omega 3.This is why they say that we need to supplement with mostly omega 3 EFAs and take few if any omega 6 EFAs.But there are crucial mistakes in this recommendation.The truth is that we are now actually overdosing on omega 3,and this is a mistake that can make you more susceptible. The following article shows how omega 3 in the dosage amounts and types often recommended by physicians and nutritionists,in particular from fi sh oil , will signifi cantly decrease your immune system response to infection.This information comes from the proceedings of the International Society for the Study of Fatty Acids and Lipids (ISSFAL)4th Congress,June 4-9,2000 in Tsukuba,Japan.1 Prepare to be shocked! “… [S ]tudies indicate that at the levels used,fi sh oil [omega 3 derivatives ]decreases a wide range of immune cell responses such as natural killer cell and cytotoxic T lymphocyte activities,lymphocyte proliferation and production of IL-2 and IFN-y (1,2)… “…Recent studies have indicated that relatively low levels of the long chain omega 3 fatty acids (EPA or DHA at a level of 4.4%of total fatty acids or 1.7%of dietary energy) are suffi cient to bring about some of the suppressive effects [on the immune system ],that dietary EPA and DHA [omega 3 derivatives ] both inhibit lymphocyte proliferation ,and that dietary EPA but not DHA inhibits natural killer cell activity .” 1 The report is titled “Omega 3 Polyunsaturated Fatty Acids,Infl ammation and Immunity,” by Philip C..Calder, Institute of Human Nutrition,University of Southampton,Bassett Crescent East,Southampton,UK. 3 These articles reveal that only a relatively small quantity of omega 3 derivatives will give rise to these immune problems.This is an immediate danger to the public, given the recent huge push in the promotion and sale of fi sh oil capsules (which are mainly omega 3 derivative-based).If you consume fi sh oil supplements ,then you will be taking a quantity of omega 3 derivatives that is signifi cantly in excess of the immune-suppressing threshold amount given in the article above.We therefore do not recommend taking omega 3 derivatives from a supplement .You may eat all the fi sh you desire,but supplement only using the guidelines given below. ***WARNING:Excess Omega 3 in Any Form is Hazardous!*** We recommend taking a very conservative amount of parent omega 3 and letting your body make its own omega 3 derivatives (from the parent omega 3),as it needs them.Note that we say take a “conservative ” amount because overdosing on parent omega 3 from fl ax seed and other parent omega 3-containing oils can also be very harmful because,in your body ’s effort to rid itself of the overdose,it too will produce more immunosuppressive omega 3 derivatives.(Note that neither Omega 6 nor its derivatives cause this immunosuppressive effect.) Rather than supplementing with fi sh oils,we recommend a plant-based omega 3 formulation (from various seeds)that contains parent omega 3 EFAs ,and NO omega 3 derivatives . Prepare to be shocked again!The article continues: “Supplementation of the diet of healthy human volunteers with fi sh-oil-derived omega 3 PUFA (1.2-1.4 gm/day*)results in decreased lymphocyte proliferation,decreased monocyte and neutrophil chemotaxis,decreased production of IL-1,IL-2,IFN- y,IL-6 and TNF,and decreased expression of MHCII and some adhesion molecules on the monocytes …” [all of which are very detrimental to your immune system ].“This decrease causes increased cellular bacteria and impaired tumor cell killing.”increased cellular bacteria and impaired tumor cell killing.”increased cellular bacteria and impaired tumor cell killing. * This is a very small amount,just a couple of capsules,to cause so much damage. Below,in the section,“The Supplement Calculation,” we provide for the fi rst time a thoroughly worked-out scientifi c analysis of the correct ratios of omega 6 to 3 to supplement with,as well as why very little omega 3 —from any supplement source — should be taken! 4 [color=red:f2bd272fe8]How Much Omega 3 and Omega 6 Are We Taking In?[/color:f2bd272fe8]What nutritionists and health commentators are missing is that most of the omega 6 EFAs in today ’s foods are ruined —they are either hydrogenated into transfats, cooked,or otherwise adulterated so they won ’t go bad on the supermarket shelf. And just looking at the harmful transfat content alone in commercial oils and oil products doesn ’t tell the whole story.Analysis of commercial “omega 6 ” oils show,in addition to lots of cancer-causing,non-oxygenating transfats,the presence of harmful preservatives and additives.Many of these additives and preservatives ruin the oils ’ oxygen--transfer capability.That ’s why traditional margarine,with perhaps a 30%transfat content,can still be kept unrefrigerated in the garage for years and no living animal will eat it —nor will it oxidize and become rancid.The remaining 70% un hydrogenated oil that supposedly isn ’t “treated ” has also lost its oxygenating ability because of preservatives and additives.Even though the oils in margarine started out with lots of healthy EFAs before processing,there is no remaining ingredient in margarine that makes it healthful. A medical article titled “Who ’s afraid of n-6 polyunsaturated fatty acids [omega 6 ]?”was published in 2001,but few in the medical and nutrition fi elds saw it.This article detailed why it is wrong to simply use only omega 3 or only omega 6 in experiments, and why experimental results are often misinterpreted.As mentioned in the fi rst paragraph above,most nutritionists and even physicians wrongly state that any extra omega 6 is “bad.” This is because they are NOT using organic unadulterated oils in most of their experiments.Researchers use ruined omega-6-containing oils,like those found at your local commercial supermarket.These are loaded with cancer-causing transfats,preservatives and other additives,so you ’d expect a problem. But the basic reason for researchers ’ distorted results are that,,under real-life conditions (which Life-Systems Engineering ALWAYS utilizes),the two healthy essential oils are consumed together most of time and only rarely apart.Researchers weren ’t adhering to real-life conditions,so the test results were wrong.It ’s that simple. The following is the pertinent phrase from the medical journal article,“Who ’s afraid of n-6 polyunsaturated fatty acids?” Berry,E.M.Nutr Metab Cardiovasc Dis 2001 Jun;11(3):181-188: “N-6 Fatty Acids [omega 6 ] are Essential for Normal Growth ....and it is therefore wrong to condemn only n-6 fatty acids in their etiology .”acids in their etiology .”acids in their etiology
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01/23/2004 11:36 AM
[quote:4e072f3883="Scott"]This is supported by the evidence that modern humans evolved near the water. [/quote:4e072f3883] Though there is some evidence that evolution may have ocurred, there is also a lot of "evidence" that it may not have. It is only a theory, albeit widely accepted but only a theory, and also still widely disputed by many, much more knowledgeable and intelligent than I. This is my only objection to your thoughts. I do not have the answers, nor claim to be scientific - just highly skeptical.
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01/23/2004 12:50 PM
[quote:3d11648f84] [b:3d11648f84]EFA SUPPLEMENT ANALYSIS[/b:3d11648f84] [color=red:3d11648f84]WARNING:Everyone is Overdosing on Omega 3[/color:3d11648f84] — Fish Oil Decreases Immunity! .The truth is that we are now actually overdosing on omega 3,and this is a mistake that can make you more susceptible. The following article shows how omega 3 in the dosage amounts and types often recommended by physicians and nutritionists,in particular from fi sh oil , will signifi cantly decrease your immune system response to infection.This information comes from the proceedings of the International Society for the Study of Fatty Acids and Lipids (ISSFAL)4th Congress,June 4-9,2000 in Tsukuba,Japan.1 Prepare to be shocked! “… [S ]tudies indicate that at the levels used,fi sh oil [omega 3 derivatives ]decreases a wide range of immune cell responses such as natural killer cell and cytotoxic T lymphocyte activities,lymphocyte proliferation and production of IL-2 and IFN-y (1,2)… “…Recent studies have indicated that relatively low levels of the long chain omega 3 fatty acids (EPA or DHA at a level of 4.4%of total fatty acids or 1.7%of dietary energy) are suffi cient to bring about some of the suppressive effects [on the immune system ],that dietary EPA and DHA [omega 3 derivatives ] both inhibit lymphocyte proliferation ,and that dietary EPA but not DHA inhibits natural killer cell activity .” 1 The report is titled “Omega 3 Polyunsaturated Fatty Acids,Infl ammation and Immunity,” by Philip C..Calder, Institute of Human Nutrition,University of Southampton,Bassett Crescent East,Southampton,UK.[/quote:3d11648f84] Sears himself has said that if your AA/EPA ratio is too low it can increase your risk of infection. This is not shocking news. However, most ailments are the result of an overactive immune response/excess inflammation (allergies, asthma, lupus, MS, arthritis), so reigning in that overactivity is a good thing. [quote:3d11648f84]If you consume fi sh oil supplements ,then you will be taking a quantity of omega 3 derivatives that is signifi cantly in excess of the immune-suppressing threshold amount given in the article above.We therefore do not recommend taking omega 3 derivatives from a supplement .You may eat all the fi sh you desire,but supplement only using the guidelines given below.[/quote:3d11648f84] That's interesting. The ISSFAL also presented a study which showed that the uptake of EPA/DHA is greater from eating fish than capsules. OOPS! [quote:3d11648f84]Note that neither Omega 6 nor its derivatives cause this immunosuppressive effect.)[/quote:3d11648f84] The studies showing the role of arachidonic acid and its metabolites in tumorigenesis are too numerous to count. [quote:3d11648f84]The following article shows how omega 3 in the dosage amounts and types often recommended by physicians and nutritionists,in particular from fi sh oil , will signifi cantly decrease your immune system response to infection [/quote:3d11648f84] [quote:3d11648f84]This article detailed why it is wrong to simply use only omega 3 or only omega 6 in experiments, and why experimental results are often misinterpreted. [/quote:3d11648f84] Hmmmm. Doesn't the latter quote put into question the former?
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01/23/2004 2:07 PM
[quote:b24aef47f3] Though there is some evidence that evolution may have ocurred, there is also a lot of "evidence" that it may not have. It is only a theory, albeit widely accepted but only a theory, and also still widely disputed by many, much more knowledgeable and intelligent than I. This is my only objection to your thoughts. I do not have the answers, nor claim to be scientific - just highly skeptical.[/quote:b24aef47f3] Thanks for your thoughts. Nothing wrong with healthy skepticism. I've often heard that if you think something is true, you'll find evidence to support it. Even proponents of evolution can't agree with each other! I'll rephrase it this way--the high need for long-chain DHA by the developing brain and eyes, in conjunction with the longer-chain fatty-acid composition of human breast milk are pretty strong indicators that our bodies prefer these fatty-acids in their long-chain form.
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01/23/2004 5:00 PM
[quote:84742278c4="Scott"]I'll rephrase it this way--the high need for long-chain DHA by the developing brain and eyes, in conjunction with the longer-chain fatty-acid composition of human breast milk are pretty strong indicators that our bodies prefer these fatty-acids in their long-chain form.[/quote:84742278c4] :wink: Thanks, Scott! :) (Much better!)
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01/23/2004 5:46 PM
Scott, your thoughts on this (and the post that follows) would be of interest.......thanks crumbelina! Life-Systems Engineering translation: [b:65fcd9e48a]We require plentyof unadulterated,unprocessed omega 6 ,regardless of what you may be told.[/b:65fcd9e48a] Moreover,the argument that omega 6 and omega 3 EFAs must be taken together and in the correct balance with each other is documented in the following quote from a medical textbook article.This article makes it clear that omega 6 and omega 3 fatty acids in combination,even at what are considered “low doses,” are more effective than omega 3 alone at higher doses.The following is the pertinent phrase: “…[There is a ] synergistic effect of n--6 [omega 6 ] and n- 3 [omega 3 ] fatty acids at low doses which is greater than the effect of high doses of n-3 fatty acids alone.” ((Prostaglandins in the Cardiovascular System,1992.) Perhaps this information won ’t stop most people from following the popular health press and medical authorities and incorrectly thinking that any extra omega 6 is “bad,” and all omega 3,,at almost any dosage,is “good.” But you will soon see how easy it is to overdose on omega 3 by following these bad recommendations . [b:65fcd9e48a]What Percentage of EFAs In Your Food Have Been Ruined?[/b:65fcd9e48a] As mentioned above,most of the omega 6 EFAs in today ’s foods are ruined — either hydrogenated into transfats or adulterated with chemicals and preservatives so the foods that contain them don ’t go bad at the supermarket or on your shelf at home. Everything from peanut butter and frozen foods to salad dressings and cooking oils is loaded with ruined omega 6 EFAs. We can safely hypothesize that,at the very minimum,the majority (51%)of the oxygen transfer capability in commercial omega 6 oils and oil-containing foods has been ruined from transfats,preservatives,and chemicals.The proof of this is that any of these oils can stay open and exposed to air for weeks before going bad,instead of just days, as unprocessed oils do!(It is obvious when oil has gone bad because it smells and tastes bad and gives off gases that release when the container is opened.)Most commercially available oils have been ruined through such processing or they would not be so “spoil- proof.” Now,with western diets containing an estimated twelve times the amount of omega 6 as omega 3,and the fact that at the very minimum,at least 51%of omega 6 EFAs are ruined as to their oxygen transfer ability,we obtain at most a 49%effectiveness of the omega 6 EFAs eaten in the normal diet.If we round these fi gures to 50%ruined versus 50%effective,it equates to an estimated 6 to 1 ratio of ef fective omega 6 EFAs to omega 3 EFAs obtained in the diet.This is actually the greatest amount of effective EFAs in the diet we could reasonably expect to fi nd.We will see below that this ratio falls slightly under our calculation of the average human requirement for EFAs. But there are further factors to consider that will affect what our ratio of omega 6 to 3 EFA supplementation should be.Even if you consumed the above ratio so you were getting a 6 to 1 ratio of effective omega 6 EFAs to omega 3 EFAs in your foods, given that at least half of it is adulterated,you would need even more “good,” organic,, unadulterated,parent omega 6 than that to compensate for the bad.Importantly,the amount of omega 3 required stays the same because there are few foods containing omega 3 that are “ruined ” in the way that omega 6 EFAs are..Let ’s continue. Are There Other Things We Need to Know? Yes,and the fi rst one is a whopper!Virtually everyone is missing a key point concerning “competition ” in the body between ruined and good omega 6::your body still uses the defective EFAs,even though they don ’t work!That is correct —your body will use the “next best thing ” in the cells if it can ’t get the parent omega 6 EFA it needs. It will use adulterated or transfat parent omega 6,it will use an EFA derivative,or it will be forced to even use the non-essential oleic acid (omega 9)that your body can either manufacture on its own or can come from foods like olive oil.But these substitutes do not provide the highest level of oxygenation for the cells.They are thus nearly worthless in improving cell respiration and health.You must therefore “overpower ” the defective EFAs you are taking in through the diet with adequate pure,unprocessed and unadulterated omega 6 EFAs to take their place. As mentioned above,the omega 3 that you get from foods is usually not adulterated.This is a further reason that more omega 6 supplementation in relation to omega 3 is needed .There is no “competition ” between good omega 3 EFAs from supplements and bad omega 3s from food,and therefore no need to overwhelm any bad omega 3 EFAs. The last factor,described in the next section,is the simple fact that the body needs and uses much less omega 3 than omega 6 overall.
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01/23/2004 5:58 PM
Let ’s continue with an examination of body tissue composition to discover what EFA ratio we require. [b:ca13e388f3]Important Organ and Tissue EFA Ratios[/b:ca13e388f3] It is necessary for us to study the EFA composition of various tissues and organs like your brain,skin,heart and muscle to discover the overall EFA requirement of the body.It is known from pathology studies that the brain and nervous system have a ratio of one part omega 6 to one part omega 3 (1 to 1). Here ’s another shocker that appeared in the medical journal article:“Fatty acid profi le of skeletal muscle phospholipids in trained and untrained young men,” Agneta Anderson (et.al),American Journal of Endocrinological Metabolism ,279:E744-E751,2000. A little-known but very key fact about muscle structure that many nutrition writers overlook is that muscle contains from 5.5 to 7.5 times more omega 6 than omega 3,depending on the degree of physical condition!(Extremely fi t individuals require less omega 6 because their oxygen-transferring effi ciency,including an increased number of cell mitochondria, is greater than in nonexercising individuals.But because most of us are not elite athletes,we require an even greater amount of omega 6.) So,on average,a muscle contains 6.5 times more omega 6 than omega 3 (a ratio of 6.5 to 1).And last,most other tissues in the body contain a 4 to 1 ratio of omega 6 to omega 3.These relationships are shown in the table below: Omega6 to Omega3 brain/nerves 1 : 1 organs, other tissue 4 : 1 muscles 6.5 : 1 The next thing to consider is what percentage of your body weight do the various organs constitute?We fi nd that brain and nerve-related organs make up only about 3% of body weight,a very small quantity.The remaining organs,such as your heart,liver, skin and pancreas,make up approximately 9%of body weight.And the last —a very important fi gure —is the percentage of body weight your muscles comprise.Muscle accounts for close to half of human body weight (50%). Now,many nutritional writers state that simply because the brain has a 1 to 1 omega 6 to 3 ratio,a 1 to 1 omega 6 to 3 ratio makes the ideal supplement.But this analysis is wrong.It should be obvious from the second table above that the majority of our EFA-containing tissues and organs (per the above chart,59%of body weight) require much more unadulterated omega 6 than omega 3 to function properly.If we use the EFA ratio of the brain and nervous system tissue (1 to 1),more than half the remaining tissues in the body will be shorted on omega 6 EFAs.On the other hand, keeping these tissues happy with enough unprocessed omega 6 is the key issue that most nutrition writers overlook.Letting any tissues run short on these omega-6 EFAs, as will occur if you follow the most prevalent nutritional recommendations,leaves your body signifi cantly more susceptible.
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01/23/2004 8:03 PM
[quote:4cb802a0e7] Moreover,the argument that omega 6 and omega 3 EFAs must be taken together and in the correct balance with each other is documented in the following quote from a medical textbook article.This article makes it clear that omega 6 and omega 3 fatty acids in combination,even at what are considered “low doses,” are more effective than omega 3 alone at higher doses.The following is the pertinent phrase: “…[There is a ] synergistic effect of n--6 [omega 6 ] and n- 3 [omega 3 ] fatty acids at low doses which is greater than the effect of high doses of n-3 fatty acids alone.” ((Prostaglandins in the Cardiovascular System,1992.)[/quote:4cb802a0e7] I don't have a problem with the above statement. In the OmegaRx Zone Sears discusses how too much omega-3 can inhibit the production of series 1("good") eicosanoids (dervived from the omega-6 linoleic acid), thus the need to balance EPA intake with GLA intake. [quote:4cb802a0e7]If we round these fi gures to 50%ruined versus 50%effective,it equates to an estimated 6 to 1 ratio of ef fective omega 6 EFAs to omega 3 EFAs obtained in the diet.This is actually the greatest amount of effective EFAs in the diet we could reasonably expect to fi nd.We will see below that this ratio falls slightly under our calculation of the average human requirement for EFAs.[/quote:4cb802a0e7] I'm not sure how they come up with the 50% figure, but comparing it with the skeletal muscle composition and coming to the conclusion that this then must be the dietary intake is flawed as I'll mention in the next post. [quote:4cb802a0e7]You must therefore “overpower ” the defective EFAs you are taking in through the diet with adequate pure,unprocessed and unadulterated omega 6 EFAs to take their place.[/quote:4cb802a0e7] Unless of course you aren't eating trans-fats and controlling insulin levels. Then the enzyme activity of the delta-6-desaturase becomes much more effective at converting the parent Omega-6 to GLA and the series 1 eicosanoids so less is needed. Too much will spillover into excess arachidonic acid.
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01/23/2004 8:22 PM
[quote:3ecbd58750] It is necessary for us to study the EFA composition of various tissues and organs like your brain,skin,heart and muscle to discover the overall EFA requirement of the body.Here ’s another shocker that appeared in the medical journal article:“Fatty acid profi le of skeletal muscle phospholipids in trained and untrained young men,” Agneta Anderson (et.al),American Journal of Endocrinological Metabolism ,279:E744-E751,2000. A little-known but very key fact about muscle structure that many nutrition writers overlook is that muscle contains from 5.5 to 7.5 times more omega 6 than omega 3,depending on the degree of physical condition!(Extremely fi t individuals require less omega 6 because their oxygen-transferring effi ciency,including an increased number of cell mitochondria, is greater than in nonexercising individuals.But because most of us are not elite athletes,we require an even greater amount of omega 6.) So,on average,a muscle contains 6.5 times more omega 6 than omega 3 (a ratio of 6.5 to 1)[/quote:3ecbd58750] The fatty acid profile of muscle is not evidence of fatty acid requirements, its a [i:3ecbd58750]consequence [/i:3ecbd58750]of dietary fatty acid composition. Anderson, Agneta, et al [i:3ecbd58750]"Fatty acid composition of skeletal muscle reflects dietary fatty acid composition in humans" [/i:3ecbd58750]American Journal of Clinical Nutrition 2002 Dec; 76(6): 1222-9. Shocking, isn't it? The fact that fit indiviudals have lower n-6/n-3 ratio than non-exercising individuals is further evidence that we need a lower ratio than what they are advocating, regardless of whether or not you are [i:3ecbd58750]fit[/i:3ecbd58750]. One of the primary hormonal responses to exercise is the lowering of insulin levels and lower accumulation of arachidonic acid. Of course, you can also lower insulin with diet. Either way, whether exercising or not, controlling insulin levels results in less arachidonic acid accumulation. The fact that non-exercising individuals have a higher skeletal muscle n-6/n-3 ratio is evidence of this accumulation, and thus not suprising that sedentary groups are at a greater risk for number of inflammatory diseases.
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01/23/2004 9:34 PM
Scott (or should I call you Dr. Sears!), thank you for your reply.... it is a lot to take in for us amateurs. I want to make sure I am understanding correctly, does this mean that muscle ratio SHOULD BE 1:1, but that unhealthy eating and inactive lifestyle cause this ratio to rise to levels of 6:1or even higher? I have learned a lot from you and the studies you have posted, you really have a way of turning even the most technical information into easy reading, you should write a book! You have so much knowledge in this area, is your work related to this field? Thanks, crumbelina
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01/25/2004 6:27 PM
[quote:bffe28fde8] I want to make sure I am understanding correctly, does this mean that muscle ratio SHOULD BE 1:1, but that unhealthy eating and inactive lifestyle cause this ratio to rise to levels of 6:1or even higher? [/quote:bffe28fde8] It would not suprise me if such a relationship exists with skeletal muscle composition, since diet influences such composition and exercise results in changes to muscle phospolipid composition to a more favorable n-6/n-3 ratio: Helge JW, et al "[i:bffe28fde8]Training affects muscle phopholipid fatty acid composition in humans[/i:bffe28fde8]" Journal of Applied Physiology 2001 Feb; 90(2):670-7 However, Sears position is that the n-6/n-3 ratio of serum phospholipid is the prime indicator for disease risk, with a 1.5-3.0 to 1 ratio of AA/EPA being ideal. Some studies have shown a relationship with erthrocyte(red blood cell) ratios and some diagnostic services do such RBC analysis (ie, Great Smokies) Heude, Barbara, et al "[i:bffe28fde8]Cognitive decline and fatty acid composition of erthrocyte membranes--The EVA study[/i:bffe28fde8]" American Journal of Clinical Nutrition , Vol. 77, No.4, 803-808, Apr 2003. It would be interesting to know what the relationship is between seurm, RBC, and muscle phospholipid composition to see the correlations. [quote:bffe28fde8]I have learned a lot from you and the studies you have posted, you really have a way of turning even the most technical information into easy reading, you should write a book![/quote:bffe28fde8] Thanks Crumbelina. I sincerely hope that the info I post is helpful. Interesting coincidence that you mention writing a book :wink: ...though I think I need to brush up on my writing and organization skills. [quote:bffe28fde8]You have so much knowledge in this area, is your work related to this field?[/quote:bffe28fde8] Not even close... :lol: Though I am back in school obtaining a second degree in biology and licensure for secondary education.
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Forums > Zone Living Forums > Zone Pals > Peskin's views on Sears.........



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Dr. Barry Sears, PhD.Dr. Barry Sears is a leading authority on the dietary control of hormonal response. A former research scientist at the Boston University School of Medicine and the Massachusetts Institute of Technology, Dr. Sears has dedicated his research efforts over the past 30 years to the study of lipids. He holds 13 U.S. Patents in the areas of intravenous drug delivery systems and hormonal regulation for the treatment of cardiovascular disease.

A turning point in his research occurred in 1982. That year, the Nobel Prize in Medicine was awarded for discoveries of the role that specialized hormones, known as eicosanoids, play in the development of cardiovascular disease, diabetes, auto-immune diseases, and cancer. Since eicosanoids are only generated from dietary fat, Dr. Sears reasoned that one could apply intravenous drug delivery principles to nutrition in order to control these exceptionally powerful hormonal responses with laser-like precision. In essence, his approach treats food as if it were a drug.

This area of his research led to various patents in the area of hormonal control by essentially using food as an oral drug delivery system to modulate eicosanoids especially for cardiovascular, diabetic, and neurological patients.

The impact of Dr. Sears’ revolutionary work in the dietary control of hormonal response began with the publication of his landmark book, The Zone. Since its publication in June 1995, The Zone has sold more than 2,000,000 hardcover copies, and became a #1 best seller on the New York Times book list. In addition, The Zone has been translated into 22 languages indicating a worldwide response to Dr. Sears’ research. His second book, Mastering the Zone, published in 1997, also became a New York Times bestseller with hardcover sales in excess of 500,000 copies to date. His third book, Zone Perfect Meals in Minutes, published in 1997, quickly became one of the best-selling cookbooks of 1997 and an another New York Times bestseller. The Anti-Aging Zone was published in 1999 and provides the molecular insights into how the Zone Diet can reverse the aging process. The Omega Rx Zone, published in 2002, explores the molecular foundation of chronic disease and how high-dose fish oil can dramatically reverse it. His latest book The Anti-Inflammation Zone discusses how to combat silent inflammation in order to reduce the risk of cancer, heart disease, diabetes, dementia, and many other inflammatory conditions—and how to reverse these conditions if they are already present. To date more than 5 million hardcover copies of his Zone books have been sold in the United States.

His research has elevated food from more than simply a source of calories to being recognized as an exceptionally powerful drug. Because of his revolutionary research, Dr. Sears has been a frequent guest on many national programs such as 20/20, Today, Good Morning America, CBS Morning News, CNN, and MSNBC.

Dr. Sears continues his ongoing research as President of Zone Labs, a biotechnology company in Danvers, MA as well as the President of the non-profit Inflammation Research Foundation in Marblehead, MA. In addition to continuing research on the hormonal effects of food, Dr. Sears has expanded his research in developing innovative dietary approaches to treating cancer and neurological conditions, as well as his on-going work in treating cardiovascular diease and type 2 diabetes.

I have been taking the Fish Oil for over 3 years now. I am 44 playing hockey and working out. The Fish oil helps with the pain that I get from playing hockey. It greatly enhances my performance on the ice and while working out. I have noticed a big difference in my energy, attentiveness and memory. If I miss a day for whatever reason, I notice a huge difference and it feels like something is missing. Anyway that is my short little story and it comes from the heart.

– Carter B.

 

I am a nutritionist and Ph.D. doctor of health and nutrition. For Dr. Sears to figure out balancing fat, carbs and protein, is really beyond brilliant. It is a milestone in diet history. I go over people's diet/emotional journals. Mostly all the time, we discover that the fatigue, irritability, unstable emotions were due to the imbalance in their diet. Using the Zone to balance them out, helps control weight, roller coaster emotions and gives them energy. Dr. Sears is so right when he says food is medicine. He has figured out the most powerful drug combination going, called The Zone.
Best and healthy wishes,

– Elaine W., Ph.D., N.C., M.A.

 

I have a very exhausting job as a flight attendant. I read the "Omega Rx Zone" about 4 years ago and started taking the fish oil. I am 47 and have been flying for 22 years. I am very active, I run and lift weights. But combining lack of regular sleep, a physically demanding job, and irregular eating patterns this job takes a toll on the body. Since taking the fish oil, I have noticed that I do not get exhausted. I get tired, but not exhausted. I stopped taking it for a couple of months and then started taking another company's fish oil. I started getting exhausted again. I came back to Zone Labs and will continue with the fish oil for the rest of my life. I believe in the product and it makes a huge difference in my life. It makes a difference with my running as well. I also bring the bars and shakes with me on the road. It is almost impossible to eat the way I should at work. I haven't found the right secret. At least I have my Zone fish oil, bars, and shakes.

– Kathryn S.

 

I have been in the Zone, for about 1 month now. I wanted to share with you how wonderful I think this program is. I have been a personal trainer for almost 10 years and actively compete in numerous athletic activities. The Zone program has helped me to achieve a better awareness of my nutritional needs and the results I have seen are amazing! I have lost nearly 13 lbs since I have been in the Zone. I feel more mentally alert, more focused at work, have greater intensity during my training, have made significant strength gains, and just feel better over all. With that said, I would like to thank you for helping me in my quest for "super-health"!
Thank you!

– Rob Y.

 

I read 'The Zone' and as exactly as I could followed the advice for diet. I noted weight loss progress. Over six months, I lost 33 pounds. One year has passed since then. I have maintained the new weight, guided always by Zone concepts. The Zone is powerful - I have found it fantastic and I am very grateful to Dr Sears.

– Lyn S.

 

Before I stumbled across the Zone I was weighing close to two hundred pounds and I was depressed. I used to be a gymnast as a young man. I would think, "look at me now," when I looked in a mirror. The day I found 'The Zone' book, I was intrigued and as I read it the science made sense and so, I began to follow the "treatment". I began to lose weight and I was feeling way more energetic. I am forty two years old, I am very active and my weight is down to 162 lbs, 38 pounds lost on the Zone. I cycle, walk, jog, swim and I can now perform some of the more simple gymnastic skills I did twenty years ago...I literally feel like I have turned back the clock.
Thank you!

– Jack J.

 

I have been on the Zone diet for 7 years. I did not go on the diet to lose weight necessarily; but fairly quickly I lost 25 pounds, going from 190 to 165; from a 36-inch waist to a 32-inch waist. I primarily did the Zone to live healthier. My health is excellent now. I just turned 62 years old. My Zone is my eating lifestyle now; I seldom stray; and I do not miss anything. It is The Good Life.

– Curtis Y.

 

My wife's doctor told her to read "Enter the Zone" and to do the diet, so I told her I would do it with her. After only one week on the plan we went on a strenuous hike (the first of the year), and when we stopped at our favorite coffee shop on the way home I was able to get out of the car and stand upright and walk into the place without pain or stiffness. The Zone had eliminated all the inflammation that had always forced me to stumble all humped over into the coffee shop any time we skied or hiked all day.
Thank you, Doctor Sears.

– Larry C.

 

I used to have a lot of knee pain when I walked or ran. I have been taking Omega Rx for almost a year now, and rarely have any pain. I believe it is the anti-inflammation action of the oil. I feel smarter as well. Thanks for developing such a superior oil!

– Joe W.

 

Prior to following the Zone Diet, my body fat was around 15% and my weight around 153 pounds. No matter what I did, my weight and body fat did not change much. I regularly cycled 20-30 hours per week logging well over 400 miles. That had little impact on body fat or weight. Diet also seemed to have little impact on body fat or weight. Within a couple of months of following the zone diet, my weight dropped rather quickly to 142 pounds and body fat to about 8%. I still regularly cycle up to 20 hours per week (during the summer). I have also started strength training. I eat about 16 blocks per day. I take 3.6 grams of fish oil per day, along with Vitamin E, Alpha Lipoic Acid, CoQ10, and B & C vitamins. I also take GLA, which in my opinion, has significantly reduced fatigue and improved recovery times after exercise.

– Jeremy S.

All polyphenols have antioxidant properties than can be measured by their Oxygen Radical Absorption Capacity (ORAC), but not all polyphenols have anti-inflammatory properties. The polyphenols in Dr. Sears’ Zone Polyphenol Plus have been carefully chosen to have both.

Polyphenols are the phytochemicals that not only give fruits and vegetables their color, but also help regulate inflammation. In addition, polyphenols also activate the key enzyme (AMP kinase) that helps restore cellular ATP levels. Polyphenols also help regulate the activation of inducible inflammatory proteins (such as COX-2 and inflammatory cytokines).

There are more than 4,000 known polyphenols, and the richest sources are fruits and vegetables. In general, the more color a fruit or vegetable has, the richer the polyphenol content.

Why OmegaRx From Zone Labs?

Certified Purity and Proven Potency

Zone Labs’ Ultra Refined Omega-3 Concentrates are three times fresher and contain less than 1/10th the mercury than what is allowed by the Norwegian Medicinal Standard and European Pharmacopoeia Standard

Zone Labs adheres to the International Fish Oil Standard (IFOS), an independent third party validated laboratory quality standard that is more rigid than any other global standard for purity.

  • No company in the worlds runs more tests with IFOS than Zone Labs
  • Zone Labs receives a 5 out of 5 star IFOS rating for every batch it tests
Standard IFOS Standard for a 5-Star Ranking Council for Responsible Nutrition European Pharmacopeia Norwegian Medicinal Standards
Peroxide < 3.75 meg/kg 5 meg/kg 10 meg/kg 10 meg/kg
Totox Levels < 20 meg/kg 26 meg/kg NA NA
Lead < 10 ppb 10 ppb 100 ppb 100 ppb
Mercury < 10 ppb 10 ppb 100 ppb 100 ppb
Dioxans and Furans < 1 ppt 2 ppt 2 ppt 2 ppt
PCBs < 45 ppb 90 ppb NA NA

 

 

 

 

 

"IFOS – THE TOP GLOBAL PURITY STANDARD FOR OMEGA-3 FROM FISH"

Zone Labs products show no detectable lead or mercury when tested down to 10ppb, which is 10 times below the Norwegian Medicinal Standard and European Pharmacopoeia Standard limits.

Zone Labs products are three times fresher than the minimum allowed by the Norwegian Medicinal Standard and European Pharmacopoeia Standards (based on average peroxide values).

 

Zone Labs starts with only wild, small fish from pristine Chilean waters and ends with proprietary validation and testing processes to achieve an IFOS certified 5 star rating.

8-Step Manufacturing Process - Quality Assured

Testing to specification all raw materials, bulk products, packaging material and finished products – always using stringent internal standards and in-process testing.

  1. Extraction of fish oil
  2. Winterization – remove limited amounts of saturated fats
  3. Absorption – remove heavy metals
  4. Preliminary Molecular Distillation – refining “touch up” to reduce contaminants
  5. Oil conversion to ethyl esters
  6. Ethyl ester thermal fractionation – remove additional saturated fats
  7. True Molecular Distillation – final refining to remove pcb’s and long-chain monoenes
  8. Rigid Processes – proprietary validation, inspection and encapsulation methods. Independent lab verification of IFOS requirements and certified 5 star rating

 

Clean Sources

No farmed fish. No large fish. Pristine waters.

Zone Labs starts with wild sardines & anchovies fished from cold, pristine waters off of South America where there are less environmental impurities.

 

A recommended serving of Zone Labs Ultra-Refined Concentrates delivers 8 times more omega-3’s than a typical retail fish oil supplement.

Most fish oil supplements have 30% or less of the healthy omega-3s EPA and DHA, with the remaining 70% of the capsule containing unbeneficial, lesser refined fatty acids that contribute to their bad taste and gastric side effects.

 

Getting a clinically valid dose of omega-3’s is easy with Zone Labs’ Ultra-Refined Omega-3 Concentrates.

Typical Retail Dose = 300mg omega-3

Standard Zone Dose = 2400mg omega-3

 

A serving of canned tuna has 12 times less omega-3’s than
Zone Labs Ultra-Refined Omega-3 Concentrates

Commonly consumed fish and shellfish in the United States

Mercury Source: Food and Drug Administration, FDA 1900-2004, “National Marine Fisheries Service Survey of Trace Elements in the Fishery Resource". Omega-3 Level Source: American Heart Association Website.

  Mercury level
in parts per million (ppm)
Omega-3 fatty acids
(milligrams per 3-oz. serving)
Zone Omega-3 Products < 0.01 2400 (standard 4 capsule serving
Salmon (fresh, frozen) 0.014 1200
Flounder or sole 0.050 480
Pollock 0.041 450
Crab 0.060 400
Scallops 0.050 290
Shrimp ND* 290
Catfish 0.050 270
Clams ND* 250
Cod 0.095 210
Canned Tuna (light) 0.120 200
* ND: Mercury concentration below detection limit.

 

OmegaRx®

Zone Labs’ leading product. OmegaRx delivers all of the benefits of Zone Labs’ ultra-refined omega-3 concentrates.

Advantages

  • Delivers clinically proven health benefits from the omega-3 fatty acids EPA and DHA*
  • Promotes a healthy heart, healthy brain, healthy immune system, healthy circulatory system, healthy joints, healthy moods, healthy triglyceride levels and a healthy pregnancy*
  • Combats silent inflammation

 

*These statements have not been evaluated by the Food and Drug Administration.

These products are not intended to diagnose, treat, cure or prevent any disease.

 

 

 

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