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zonelifter  Posts:0
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| 01/06/2005 3:48 PM |
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| zoneadept - Thanks for the link. I haven't had a chance to look at it in detail, but it looks to be a very valuable source of AA content data. Do you know if it uses the USDA database for its data source? Or does it use data derived from testing independant from the USDA's testing?
Scott - Thanks for your comments. For the last 2 allergy seasons (Spring and Fall 2004), I have used 2400mg EPA and 1200mg DHA (6 capsules) daily to go along with the 440mg of GLA to get complete relief from allergy symptoms. My first experience with high dose fish oil was in 2003 immediately after I read the "OmegaRx Zone." I
immediately began using 7.5 g of EPA & DHA (1 tablespoon per day of the liquid OmegaRx). During that season, my allergy symptoms were dramatically reduced (though not completely relieved). Still, I was quite happy with the results until I began to experience extreme fatigue about 6 weeks after beginning supplementation. After doing
some research (primarily the Holub papers), I suspected that low DGLA levels might be the cause, so I bought some borage oil to try. I experienced a dramatic improvement in my fatigue after my very first borage oil dose (220mg GLA). That experience was very consistent with your comments that high dose fish oil can reduce GLA production as well as with Holub's research that indicated that 4g of EPA/DHA per day dramatically reduced DGLA levels.
Consistent with your comments, I am contemplating reducing fish oil supplementation levels further. I am curious to know if I can get the same results with the reduced EPA/DHA supplementation. Perhaps I can reduce my GLA supplementation accordingly and still get the same results. The next allergy season isn't for several months, so I
have a while before I can evaluate it. I'm also keeping my eye on the advancement of blood testing for AA, EPA, DHA, & DGLA levels. Ideally, I would like to do that on a regular basis if the cost and ease of performance continue to improve. I also use the eiconsanoid status report, but experience has taught me that a good eisosanoid status
report does not necessarily give me good allergy symptom relief once the allergy season hits - so I've come to rely on my allergy symptom relief as my primary indicator of my zone & fatty acid level status.
Thanks again for your comments. I appreciate your thoughts.
Terry |
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Scott  Posts:0
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| 01/06/2005 5:15 PM |
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| [quote:9a91d39f76="zonadept"]SCott,
Have a look at the AA content of common food:
http://www.nutritiondata.com/foods-000064000000000000000-w5.html
If the link doesn't work, do the search yourself.[/quote:9a91d39f76]
First--thanks for the link--pretty neat setup.
Second-the amounts on that table (highest in 20:4) were in 6-block portions--so I had to prorate to one block increments.
In choosing a few of what appeared to be [i:9a91d39f76]favorable[/i:9a91d39f76] choices (chicken/turkey)--a lot of unfavorables in the list-- it looks as if it comes to between 30-40mg AA per protein block. So let's say you have two meals per day that include these foods. At 8 blocks (average male for two meals) you'd get close to 280mg.
Next you fine tune with EPA and GLA such that along with your average dietary intake of AA coupled with your protein-carb ratio and its impact on D5D, you find your self checking off more positive marks on the ESR. Or you are more exact and get an AA/EPA test. It seems to me that since the amount of EPA and GLA arrived at was in conjunction with your current dietary AA intake--dietary sources become irrelevant provided you are consistent with your average AA intake. What IS relevant is the amount of GLA it takes to begin an [i:9a91d39f76]accumulation[/i:9a91d39f76] of AA in the phospholipids. Or if you happen to take in more AA on a certain day. There also may be an inherent difference in how the body metabolizes dietary sources of AA vs. AA derived from GLA in the cellular membranes. Is the excess dietary AA taken in on a given day (since your EPA/GLA was derived along with an average AA intake) incorporated into the cellular membranes to the same extent as the desaturation of DGLA.
Ultimately, one would think that as long as DGLA rises higher relative to any increase in AA, you should be ok. |
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Scott  Posts:0
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| 01/06/2005 5:48 PM |
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| [quote:aae8ffddcd="zonelifter"]After doing some research (primarily the Holub papers), I suspected that low DGLA levels might be the cause, so I bought some borage oil to try. I experienced a dramatic improvement in my fatigue after my very first borage oil dose (220mg GLA). That experience was very consistent with your comments that high dose fish oil can reduce GLA production as well as with Holub's research that indicated that 4g of EPA/DHA per day dramatically reduced DGLA levels.
Consistent with your comments, I am contemplating reducing fish oil supplementation levels further. I am curious to know if I can get the same results with the reduced EPA/DHA supplementation. Perhaps I can reduce my GLA supplementation accordingly and still get the same results. [/quote:aae8ffddcd]
I am very interested in your results. Further to your experience, Holub published a paper in 2003 which looked at 4g EPA/DHA coupled with 0gGLA, 1gGLA, 2gGLA, and 4gGLA. The 4:2 group experienced a decrease in LDL. Prostaglandin E1 is known to increase the receptor binding for LDL, so it seems that a 4:2 ratio of EPA/DHA to GLA provided the greatest increase in "good" eicosanoids. EPA/DHA alone did not increase DGLA signifcantly, and 4:4 may have increased AA more so than the rise in DGLA.
Now these were women probably on a standard western diet so the relative of amounts needed would change following Zone principles (most likely less GLA given increased enzyme activity), but it does highlight the importance of finding that optimal GLA/EPA balance.
Laidlaw M, Holub BJ [i:aae8ffddcd]"Effects of supplementation with fish oil-derived n-3 fatty acids and gamma-linolenic acid on circulating plasma lipids and fatty acid profiles in women." [/i:aae8ffddcd]American Journal of Clinical Nutition 2003 Jan;77(1):37-42 |
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Scott  Posts:0
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| 01/07/2005 1:35 AM |
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| [quote:8e1ee2e216="zonelifter"]Still, I was quite happy with the results until I began to experience extreme fatigue about 6 weeks after beginning supplementation. After doing
some research (primarily the Holub papers), I suspected that low DGLA levels might be the cause, so I bought some borage oil to try. I experienced a dramatic improvement in my fatigue after my very first borage oil dose (220mg GLA). [/quote:8e1ee2e216]
I'm curious whether the extra GLA eliminated the fatigue due to higher DGLA, or what ultimately would be come more AA. Too many vasodilating (ie "good") eicocanoids that can occur from higher omega-3s can promote electrolyte loss and induce fatigue.
[quote:8e1ee2e216] I'm also keeping my eye on the advancement of blood testing for AA, EPA, DHA, & DGLA levels. Ideally, I would like to do that on a regular basis if the cost and ease of performance continue to improve. [/quote:8e1ee2e216]
When my wife had the AA/EPA test, I asked for a breakdown of all the fatty acids and was able to get numbers for DGLA, GLA, DHA etc. Unfortunately, I havn't see much data on an optimal serum DGLA/AA ratio |
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Dennis  Posts:1
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| 01/07/2005 12:46 PM |
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| [quote:4d4ae3bddd="zonelifter"]In my own experience, I have found increased GLA supplementation (up to 440mg/day) to be very beneficial. Using GLA supplementation at that level along with high dose fish oil has given me considerably better results than high dose fish oil alone. So much so, in fact, that I have been able to completely eliminate allergy symptoms for the last couple of seasons. Still, I worry about the spillover effect since Dr. Sears seems to emphasize it so much. Based on my experience, I speculate that I may have a reduced D6D activity (even when following the zone dietary principals) - which may explain the discrepancy between my experience and zone theory.[/quote:4d4ae3bddd]
Quite interesting. I had the opposite experience with my seasonal allergies and fatigue. I had been taking high dose GLA for years to no benefit. When I started the Zone diet, I started on high dose PGFO. After feeling good for a week, I would become fatigued. I found that I had to keep increasing my PGFO and decreasing dietary sources of GLA to continue to feel better. Finally with 27g of PGFO and minimal GLA, my allergy symptoms have virtually vanished and I never feel fatigued now. |
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Gent  Posts:0
 Newbie
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| 01/07/2005 1:23 PM |
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| Hi to all,
some considerations come to mind:
a) in a calorie restriction regime diet, like in the Zone, the activity of D6D increases up to 300%;
b) Horrobin et al.*) have shown that linoleic acid may be rapidly converted to arachidonic acid by a tightly linked enzyme sequence: GLA, in contrast, may be rapidly converted to DGLA but then only slowly on to arachidonic acid. However in some other studies assumption of GLA without EPA has been shown to increase AA serum levels.
c) in the Zone OmegaRX LA and AA assumption with diet is at low-moderate levels and insulin, a major D5D stimulating factor, is kept under control; adeguate amounts of EPA further inhibit D5D activity.
d) Rubin D, Laposata M. **) have shown that:
1) n-6 fatty acids markedly stimulated the elongation of EPA to 22:5 whereas n-3 fatty acids inhibited the delta 5 desaturation of DHLA to AA and the elongation of AA to 22:4; 2) n-6 fatty acids caused a specific redistribution of cellular EPA from phospholipid to triacylglycerol; 3) n-3 fatty acids reduced the mass of DHLA and AA only in phosphatidylinositol whereas n-6 fatty acids reduced the mass of EPA to a similar extent in all cellular phospholipids; and 4) n-3 fatty acids caused an identical (33%) reduction in the bradykinin-induced release of PGE1 and PGE2, whereas n-6 fatty acids stimulated PGE3 release 2.3-fold.
The Sears' anectodical evidence on the "spill-over effect" was observed in people that were taking supplements with a fairly high GLA:EPA ratio, while not following the Zone and not controlling their overall LA intake.
I believe that in a diet with the maintenance EPA+DHA level (2,5g), unless large amounts of GLA are assumed on a continuous basis with diet, it should be difficult to observe any "spill-over" effect.
*) Horrobin DF, Ells KM, Morse-Fisher N, Manku MS. The effects of evening primrose oil, safflower oil and paraffin on plasma fatty acid levels in humans: choice of an appropriate placebo for clinical studies on primrose oil.Prostaglandins Leukot Essent Fatty Acids. 1991 Apr;42(4):245-9.
**) Rubin D, Laposata M. Cellular interactions between n6 and n3
acids: a mass analysis of fatty acid elongation/desaturation, distribution
among complex lipids and conversion to eicosanoids. J Lipid Res
1992;33:1431–40. |
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zonadept  Posts:0
 Newbie
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| 01/07/2005 3:18 PM |
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| [quote:787eaf7e6f="Gent"]I believe that in a diet with the maintenance EPA+DHA level (2,5g), unless large amounts of GLA are assumed on a continuous basis with diet, it should be difficult to observe any "spill-over" effect.
[/quote:787eaf7e6f]
I spill-over very easily even with 2.5g of epa+dha.
Now, I think that the spill-over effect has nothing to do with the plasma AA. The reason is that we get around 400mg a day on a zone diet. Anecdotally, with 50mg a day of GLA, I spill over, but not with 450mg of AA, to make it short.
I'm sorry to say again that the 2mg of GLA twice a day in the form of a bowl of oatmeal doesn't make any sense at all.
From USDA, here's a list of food containing GLA (GLA in mg for 100g of food):
Lean beef : 13
avocado : 15
pine nuts: 52
peanuts: 38
brazilnuts: 17
turkey saussage: 13
Chicken, pork : 50 |
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Gent  Posts:0
 Newbie
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| 01/07/2005 4:55 PM |
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| Hi zonadept,
[quote:df01f685f5="zonadept"]
I spill-over very easily even with 2.5g of epa+dha.
Now, I think that the spill-over effect has nothing to do with the plasma AA. The reason is that we get around 400mg a day on a zone diet. Anecdotally, with 50mg a day of GLA, I spill over, but not with 450mg of AA, to make it short.
[/quote:df01f685f5]
but that's the point: are you sure you're "spilling-over" i.e. increasing AA concentration at the expense of DGLA?
Horrobin has shown in an animal model that when the activity of D6D was at its peak , supplementation with GLA didn't bring significant changes in DGLA, GLA and AA concentrations. It was only in the elderly that such supplementation did make a difference.
In my personal experience, when I've supplemented with around 50mg of GLA taking 3,6g of EPA+DHA I've noticed that the eico-signals were more in the sense of too many "goods" around. |
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Scott  Posts:0
 Newbie
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| 01/07/2005 5:14 PM |
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| Thanks for your insights, Gent.
[quote:6734c72ef3="zonadept"]
Now, I think that the spill-over effect has nothing to do with the plasma AA. The reason is that we get around 400mg a day on a zone diet. Anecdotally, with 50mg a day of GLA, I spill over, but not with 450mg of AA, to make it short.[/quote:6734c72ef3]
Again, there may be a difference in AA derived from the desaturation of DGLA already withing the cellular membranes, then from dietary AA.
[quote:6734c72ef3]
From USDA, here's a list of food containing GLA (GLA in mg for 100g of food):
Lean beef : 13
avocado : 15
pine nuts: 52
peanuts: 38
brazilnuts: 17
turkey saussage: 13
Chicken, pork : 50[/quote:6734c72ef3]
The composition of the fatty acids within a food can impact how GLA is incorporated. |
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zonelifter  Posts:0
 Newbie
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| 01/07/2005 7:28 PM |
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| Scott wrote:
[quote:fb1a397897]
I'm curious whether the extra GLA eliminated the fatigue due to higher DGLA, or what ultimately would be come more AA. Too many vasodilating (ie "good") eicocanoids that can occur from higher omega-3s can promote electrolyte loss and induce fatigue.
[/quote:fb1a397897]
Scott,
I think you may be on to something here. At the time, I did not consider this possibilty since I didn't seem to have any other vasodilating symptoms per the eicosanoid status
report. Now, a year and 1/2 wiser/more experienced in the zone, I see the possibility. I'll need to give it some more thought now (while keeping that possibility in mind).
Thanks for the thought!
Terry |
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Gent  Posts:0
 Newbie
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| 01/12/2005 10:38 AM |
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| Hi Zonadept,
[quote:81f79511ca="zonadept"][quote:81f79511ca="Gent"]I believe that in a diet with the maintenance EPA+DHA level (2,5g), unless large amounts of GLA are assumed on a continuous basis with diet, it should be difficult to observe any "spill-over" effect.
[/quote:81f79511ca]
I spill-over very easily even with 2.5g of epa+dha.
Now, I think that the spill-over effect has nothing to do with the plasma AA. The reason is that we get around 400mg a day on a zone diet. Anecdotally, with 50mg a day of GLA, I spill over, but not with 450mg of AA, to make it short.
[/quote:81f79511ca]
there are ways other than “spill-over” on how GLA would affect the eicosanoid equilibrium 1-2).
It is known that the elongation of GLA to DGLA occurs more rapidly than the successive desaturation step, the more so in the presence of EPA.
Maintaining the same levels of EPA assumption and increasing those of GLA, the phospholipids concentration of DGLA might slightly increase, at the expense of EPA phospholipids concentration - given a preferential cellular retention capacity of AA. - via shifting more EPA to triacylglycerol fraction and stimulating its elongation to DPA (22:5).
The ratio AApl/AAtg : DGLApl/DGLAtg i.e. the distribution of AA between the phospholipids and triglyceride cellular fractions [i:81f79511ca]versus [/i:81f79511ca]that of DGLA remains stable at an average level of 5,39.
Moreover AA is mostly concentrated in the phosphatidylinositol (PI) fraction of the phospholipids pool, while DGLA and EPA are fairly equally distributed in all the fractions. A reduction in the EPA concentration would eventually allow a slightly greater amount of DGLA being converted on to AA, and, more importantly, allow a greater up-take of AA into phospholipids pool. Thus, as an effect of increased assumption of GLA, the respective ratios DGLA/AA and EPA/AA in the PI fraction may worsen.
Given that the PI fraction is one of the major donors of eicosanoids' precursors, the end result may be a worsening of the eicosanoid equilibrium (more bad v. good) perceived as a "spill-over" effect.
1) Rubin D, Laposata M. Cellular interactions between n 6 and n 3
acids: a mass analysis of fatty acid elongation/desaturation, distribution
among complex lipids and conversion to eicosanoids. J Lipid Res
1992;33:1431–40.
2) Rubin D, Laposata M. Regulation of agonist-induced prostaglandin E1 versus prostaglandin E2 production J. Bio. Chemistry 1991 |
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ActiveForums 3.6
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Dr. Barry Sears is a leading authority on the dietary control of hormonal response. A former research scientist at the Boston University School of Medicine and the Massachusetts Institute of Technology, Dr. Sears has dedicated his research efforts over the past 30 years to the study of lipids. He holds 13 U.S. Patents in the areas of intravenous drug delivery systems and hormonal regulation for the treatment of cardiovascular disease.
A turning point in his research occurred in 1982. That year, the Nobel Prize in Medicine was awarded for discoveries of the role that specialized hormones, known as eicosanoids, play in the development of cardiovascular disease, diabetes, auto-immune diseases, and cancer. Since eicosanoids are only generated from dietary fat, Dr. Sears reasoned that one could apply intravenous drug delivery principles to nutrition in order to control these exceptionally powerful hormonal responses with laser-like precision. In essence, his approach treats food as if it were a drug.
This area of his research led to various patents in the area of hormonal control by essentially using food as an oral drug delivery system to modulate eicosanoids especially for cardiovascular, diabetic, and neurological patients.
The impact of Dr. Sears’ revolutionary work in the dietary control of hormonal response began with the publication of his landmark book, The Zone. Since its publication in June 1995, The Zone has sold more than 2,000,000 hardcover copies, and became a #1 best seller on the New York Times book list. In addition, The Zone has been translated into 22 languages indicating a worldwide response to Dr. Sears’ research. His second book, Mastering the Zone, published in 1997, also became a New York Times bestseller with hardcover sales in excess of 500,000 copies to date. His third book, Zone Perfect Meals in Minutes, published in 1997, quickly became one of the best-selling cookbooks of 1997 and an another New York Times bestseller. The Anti-Aging Zone was published in 1999 and provides the molecular insights into how the Zone Diet can reverse the aging process. The Omega Rx Zone, published in 2002, explores the molecular foundation of chronic disease and how high-dose fish oil can dramatically reverse it. His latest book The Anti-Inflammation Zone discusses how to combat silent inflammation in order to reduce the risk of cancer, heart disease, diabetes, dementia, and many other inflammatory conditions—and how to reverse these conditions if they are already present. To date more than 5 million hardcover copies of his Zone books have been sold in the United States.
His research has elevated food from more than simply a source of calories to being recognized as an exceptionally powerful drug. Because of his revolutionary research, Dr. Sears has been a frequent guest on many national programs such as 20/20, Today, Good Morning America, CBS Morning News, CNN, and MSNBC.
Dr. Sears continues his ongoing research as President of Zone Labs, a biotechnology company in Danvers, MA as well as the President of the non-profit Inflammation Research Foundation in Marblehead, MA. In addition to continuing research on the hormonal effects of food, Dr. Sears has expanded his research in developing innovative dietary approaches to treating cancer and neurological conditions, as well as his on-going work in treating cardiovascular diease and type 2 diabetes.
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I have been taking the Fish Oil for over 3 years now. I am 44 playing hockey and working out. The Fish oil helps with the pain that I get from playing hockey. It greatly enhances my performance on the ice and while working out. I have noticed a big difference in my energy, attentiveness and memory. If I miss a day for whatever reason, I notice a huge difference and it feels like something is missing. Anyway that is my short little story and it comes from the heart.
– Carter B.
I am a nutritionist and Ph.D. doctor of health and nutrition. For Dr. Sears to figure out balancing fat, carbs and protein, is really beyond brilliant. It is a milestone in diet history. I go over people's diet/emotional journals. Mostly all the time, we discover that the fatigue, irritability, unstable emotions were due to the imbalance in their diet. Using the Zone to balance them out, helps control weight, roller coaster emotions and gives them energy. Dr. Sears is so right when he says food is medicine. He has figured out the most powerful drug combination going, called The Zone.
Best and healthy wishes,
– Elaine W., Ph.D., N.C., M.A.
I have a very exhausting job as a flight attendant. I read the "Omega Rx Zone" about 4 years ago and started taking the fish oil. I am 47 and have been flying for 22 years. I am very active, I run and lift weights. But combining lack of regular sleep, a physically demanding job, and irregular eating patterns this job takes a toll on the body. Since taking the fish oil, I have noticed that I do not get exhausted. I get tired, but not exhausted. I stopped taking it for a couple of months and then started taking another company's fish oil. I started getting exhausted again. I came back to Zone Labs and will continue with the fish oil for the rest of my life. I believe in the product and it makes a huge difference in my life. It makes a difference with my running as well. I also bring the bars and shakes with me on the road. It is almost impossible to eat the way I should at work. I haven't found the right secret. At least I have my Zone fish oil, bars, and shakes.
– Kathryn S.
I have been in the Zone, for about 1 month now. I wanted to share with you how wonderful I think this program is. I have been a personal trainer for almost 10 years and actively compete in numerous athletic activities. The Zone program has helped me to achieve a better awareness of my nutritional needs and the results I have seen are amazing! I have lost nearly 13 lbs since I have been in the Zone. I feel more mentally alert, more focused at work, have greater intensity during my training, have made significant strength gains, and just feel better over all. With that said, I would like to thank you for helping me in my quest for "super-health"!
Thank you!
– Rob Y.
I read 'The Zone' and as exactly as I could followed the advice for diet. I noted weight loss progress. Over six months, I lost 33 pounds. One year has passed since then. I have maintained the new weight, guided always by Zone concepts. The Zone is powerful - I have found it fantastic and I am very grateful to Dr Sears.
– Lyn S.
Before I stumbled across the Zone I was weighing close to two hundred pounds and I was depressed. I used to be a gymnast as a young man. I would think, "look at me now," when I looked in a mirror. The day I found 'The Zone' book, I was intrigued and as I read it the science made sense and so, I began to follow the "treatment". I began to lose weight and I was feeling way more energetic. I am forty two years old, I am very active and my weight is down to 162 lbs, 38 pounds lost on the Zone. I cycle, walk, jog, swim and I can now perform some of the more simple gymnastic skills I did twenty years ago...I literally feel like I have turned back the clock.
Thank you!
– Jack J.
I have been on the Zone diet for 7 years. I did not go on the diet to lose weight necessarily; but fairly quickly I lost 25 pounds, going from 190 to 165; from a 36-inch waist to a 32-inch waist. I primarily did the Zone to live healthier. My health is excellent now. I just turned 62 years old. My Zone is my eating lifestyle now; I seldom stray; and I do not miss anything. It is The Good Life.
– Curtis Y.
My wife's doctor told her to read "Enter the Zone" and to do the diet, so I told her I would do it with her. After only one week on the plan we went on a strenuous hike (the first of the year), and when we stopped at our favorite coffee shop on the way home I was able to get out of the car and stand upright and walk into the place without pain or stiffness. The Zone had eliminated all the inflammation that had always forced me to stumble all humped over into the coffee shop any time we skied or hiked all day.
Thank you, Doctor Sears.
– Larry C.
I used to have a lot of knee pain when I walked or ran. I have been taking Omega Rx for almost a year now, and rarely have any pain. I believe it is the anti-inflammation action of the oil. I feel smarter as well. Thanks for developing such a superior oil!
– Joe W.
Prior to following the Zone Diet, my body fat was around 15% and my weight around 153 pounds. No matter what I did, my weight and body fat did not change much. I regularly cycled 20-30 hours per week logging well over 400 miles. That had little impact on body fat or weight. Diet also seemed to have little impact on body fat or weight. Within a couple of months of following the zone diet, my weight dropped rather quickly to 142 pounds and body fat to about 8%. I still regularly cycle up to 20 hours per week (during the summer). I have also started strength training. I eat about 16 blocks per day. I take 3.6 grams of fish oil per day, along with Vitamin E, Alpha Lipoic Acid, CoQ10, and B & C vitamins. I also take GLA, which in my opinion, has significantly reduced fatigue and improved recovery times after exercise.
– Jeremy S.
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All polyphenols have antioxidant properties than can be measured by their Oxygen Radical Absorption Capacity (ORAC), but not all polyphenols have anti-inflammatory properties. The polyphenols in Dr. Sears’ Zone Polyphenol Plus have been carefully chosen to have both.
Polyphenols are the phytochemicals that not only give fruits and vegetables their color, but also help regulate inflammation. In addition, polyphenols also activate the key enzyme (AMP kinase) that helps restore cellular ATP levels. Polyphenols also help regulate the activation of inducible inflammatory proteins (such as COX-2 and inflammatory cytokines).
There are more than 4,000 known polyphenols, and the richest sources are fruits and vegetables. In general, the more color a fruit or vegetable has, the richer the polyphenol content.
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Zone Labs’ Ultra Refined Omega-3 Concentrates are three times fresher and contain less than 1/10th the mercury than what is allowed by the Norwegian Medicinal Standard and European Pharmacopoeia Standard
Zone Labs adheres to the International Fish Oil Standard (IFOS), an independent third party validated laboratory quality standard that is more rigid than any other global standard for purity.
- No company in the worlds runs more tests with IFOS than Zone Labs
- Zone Labs receives a 5 out of 5 star IFOS rating for every batch it tests
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| Standard |
IFOS Standard for a 5-Star Ranking |
Council for Responsible Nutrition |
European Pharmacopeia |
Norwegian Medicinal Standards |
| Peroxide |
< 3.75 meg/kg |
5 meg/kg |
10 meg/kg |
10 meg/kg |
| Totox Levels |
< 20 meg/kg |
26 meg/kg |
NA |
NA |
| Lead |
< 10 ppb |
10 ppb |
100 ppb |
100 ppb |
| Mercury |
< 10 ppb |
10 ppb |
100 ppb |
100 ppb |
| Dioxans and Furans |
< 1 ppt |
2 ppt |
2 ppt |
2 ppt |
| PCBs |
< 45 ppb |
90 ppb |
NA |
NA |
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"IFOS – THE TOP GLOBAL PURITY STANDARD FOR OMEGA-3 FROM FISH"
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Zone Labs products show no detectable lead or mercury when tested down to 10ppb, which is 10 times below the Norwegian Medicinal Standard and European Pharmacopoeia Standard limits.
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Zone Labs products are three times fresher than the minimum allowed by the Norwegian Medicinal Standard and European Pharmacopoeia Standards (based on average peroxide values).
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Zone Labs starts with only wild, small fish from pristine Chilean waters and ends with proprietary validation and testing processes to achieve an IFOS certified 5 star rating.
8-Step Manufacturing Process - Quality Assured
Testing to specification all raw materials, bulk products, packaging material and finished products – always using stringent internal standards and in-process testing.
- Extraction of fish oil
- Winterization – remove limited amounts of saturated fats
- Absorption – remove heavy metals
- Preliminary Molecular Distillation – refining “touch up” to reduce contaminants
- Oil conversion to ethyl esters
- Ethyl ester thermal fractionation – remove additional saturated fats
- True Molecular Distillation – final refining to remove pcb’s and long-chain monoenes
- Rigid Processes – proprietary validation, inspection and encapsulation methods. Independent lab verification of IFOS requirements and certified 5 star rating
No farmed fish. No large fish. Pristine waters.
Zone Labs starts with wild sardines & anchovies fished from cold, pristine waters off of South America where there are less environmental impurities.
A recommended serving of Zone Labs Ultra-Refined Concentrates delivers 8 times more omega-3’s than a typical retail fish oil supplement.
Most fish oil supplements have 30% or less of the healthy omega-3s EPA and DHA, with the remaining 70% of the capsule containing unbeneficial, lesser refined fatty acids that contribute to their bad taste and gastric side effects.
Getting a clinically valid dose of omega-3’s is easy with Zone Labs’ Ultra-Refined Omega-3 Concentrates.
Typical Retail Dose = 300mg omega-3
Standard Zone Dose = 2400mg omega-3
A serving of canned tuna has 12 times less omega-3’s than
Zone Labs Ultra-Refined Omega-3 Concentrates
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Commonly consumed fish and shellfish in the United States
Mercury Source: Food and Drug Administration, FDA 1900-2004, “National Marine Fisheries Service Survey of Trace Elements in the Fishery Resource". Omega-3 Level Source: American Heart Association Website.
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Mercury level
in parts per million (ppm) |
Omega-3 fatty acids
(milligrams per 3-oz. serving) |
| Zone Omega-3 Products |
< 0.01 |
2400 (standard 4 capsule serving |
| Salmon (fresh, frozen) |
0.014 |
1200 |
| Flounder or sole |
0.050 |
480 |
| Pollock |
0.041 |
450 |
| Crab |
0.060 |
400 |
| Scallops |
0.050 |
290 |
| Shrimp |
ND* |
290 |
| Catfish |
0.050 |
270 |
| Clams |
ND* |
250 |
| Cod |
0.095 |
210 |
| Canned Tuna (light) |
0.120 |
200 |
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Zone Labs’ leading product. OmegaRx delivers all of the benefits of Zone Labs’ ultra-refined omega-3 concentrates.
Advantages
- Delivers clinically proven health benefits from the omega-3 fatty acids EPA and DHA*
- Promotes a healthy heart, healthy brain, healthy immune system, healthy circulatory system, healthy joints, healthy moods, healthy triglyceride levels and a healthy pregnancy*
- Combats silent inflammation
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