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Dennis  Posts:1
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| 10/12/2004 2:05 AM |
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| [quote:1295cef1e7="Fatboyslim"]I assume you zone fervently.[/quote:1295cef1e7]
Yes, I could be called a poster boy for the Zone.
[quote:1295cef1e7="Fatboyslim"]I don't appear to have much sensitivity to pgfo, so I can't really relate to your effects. I take a little, I take a lot, I can't tell much diff. Maybe if I upped the dose a *long* way I would get an effect?[/quote:1295cef1e7]
The eicosanoid status sheet (my modified version, of course) did not register anything but too much AA until I got to about 20g of PGFO. Then I started to see better and better results up to 27g. After that, I started to show signs of too much EPA. When I was at 8g, I got an AA/EPA test. From the raw AA and EPA numbers I calculated that I would need between 24g and 36g to get in the proper zone. I was right on. I am waiting on my MD to set up an account to get another AA/EPA test done very soon. This should verify my results. I need to keep my intake at 27g+/-1g. I am a real canary! If I up my exercise level (due to work) I start feeling the effects of a lower AA/EPA ratio, and I have to drop 1g. I am an extreme case. I don't expect there are many who could tolerate as much PGFO as I need. If CNO changes the uptake efficiency of my PGFO by even 10%, I will know it after a few days. However, since I am already taking almost 60% of my calories in fat, and I am not changing the total fat, the CNO would have to be uniquely synergistic to have an effect. |
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Fatboyslim  Posts:0
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| 10/12/2004 3:19 PM |
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| To Sue: Your story, and your son's, is truly remarkable. I've seen it before and been just amazed. If I remember correctly, you ended up only taking 1/5 tsp every 2 days or something like that. To me, it's remarkable that you go from high bp and meds to nothing on just 1/5 tsp every other day. Really highlights the point that everyone biochemistry is unique!! (My sone is a fr at college also. His fridge is stocked with bottles too, but I'm fairly certain his is not pgfo)
And now, other questions. Did you ever try cod liver oil? It would have done the same thing as pgfo. Depending on timing, pgfo may not have been available.
Did you have other effects? This one, plus you son's skin, is major, but were there others from pgfo?
To Dennis: Your bp dropping was normal. It seems almost everyone's does. Mine did also, about 15 points.
The fats you are taking. What kind are they? I think it will matter when you check to see if cno will have any special synergism. You're as good a guinea pig as me!! Except you're more aware of your situation, so maybe you're better!! :P |
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Dennis  Posts:1
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| 10/12/2004 3:55 PM |
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| [quote:2cf6aa2c48="Fatboyslim"]The fats you are taking. What kind are they? I think it will matter when you check to see if cno will have any special synergism.[/quote:2cf6aa2c48]
Bob,
Most of my fats are: PGFO, Olive oil, and ground Pecans --about equal amounts of each. High in mono-unsaturated fats and long chain Omega-3, Very low in saturated fats. I replaced some Pecans with fresh Coconut for the experiment.
BTW, I see that Tropical Traditions is running a big sale right now on two gallons of Virgin CNO. $50/gallon. That is a significant discount! |
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Fatboyslim  Posts:0
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| 10/12/2004 8:25 PM |
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| Dennis,
That's good that your fats are mostly mufa or pufa, not sfa. (Jeez it looks like some kind of foreign language!) My test will be mostly mufa, but I intake some SFA. When I get done with the test I'm increasing my SFA back to where it was, and maybe adding more. I'm starting to come to the conclusion that SFA is getting a bad rap it doesn't deserve. It's been said that when people started eating beef rather than fish is when heart disease and cancer showed up. I disagree. Go spend some time in the midwest plains, without a lake within 200 miles, and tell me they ever survived on fish. No, I think that when people stopped eating SFA and started eating PUFA is when the fit hit the shan. So no one takes this as gospel, it is my opinion!! When EPA and DHA come only from cold-water fish, then to say we came from somewhere in Africa(not really cold there), OK, it's story time. So there's room for interpretation. |
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Scott  Posts:0
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| 10/13/2004 5:02 PM |
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| [quote:3f086a725e="Fatboyslim"] It's been said that when people started eating beef rather than fish is when heart disease and cancer showed up. I disagree. Go spend some time in the midwest plains, without a lake within 200 miles, and tell me they ever survived on fish.[/quote:3f086a725e]
First, the n-6/n-3 fatty-acid profile of free-range animals is much more favorable compared to feed-lot beef (less than 3.0) The polyunsaturated-saturated ratio is about 1.0 (not high in SFA at all), brains are high in DHA, and marrow is close to 50% mufa.
Cordain L, et al [i:3f086a725e]"Fatty acid analysis of wild ruminant tissues: evolutionary implications for reducing diet-related chronic disease"[/i:3f086a725e] Eur J Clin Nutr 2002 Mar;56(3):181-91
Second, the amount of time humans have spent on the midwest plains is a drop in the bucket compared to the time it took for the human brain to evolve.
[quote:3f086a725e]When EPA and DHA come only from cold-water fish, then to say we came from somewhere in Africa(not really cold there), OK, it's story time. So there's room for interpretation.[/quote:3f086a725e]
The freshwater fish and shellfish that were present in the African Rift Valley were very rich in LCPUFAs, and are believed to be the driving force behind the evolution of the human brain without a corresponding increase in body size.
Broadhurst CL, et al [i:3f086a725e]"Brain-specific lipids from marine, lacustrine or terrestrial food resources: potential impact on early African Homo sapiens"[/i:3f086a725e] Comp Biochem Physiol B Biochem Mol Biol. 2002 Apr;131(4):653-73
Broadhurst CL, et al [i:3f086a725e]"Rift Valley lake fish and shellfish provided brain-specific nutrients for early Homo."[/i:3f086a725e] Br J Nutrition 1998 Jan;79(1):3-21 |
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Dennis  Posts:1
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| 10/13/2004 7:07 PM |
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| Scott/Bob, et al.,
Reading all the references on the internet about fats, really made my head swim. So many opposing views out there. :? However, this is a really important subject to get right for our health!
:idea: A few days ago, I started to try and write "Fats in a Nutshell" to post here as a new topic so we can continue this subject in its own thread (it deserves it). It may take a few more days to put it into good enough shape to post and everyone start poking at it. I am trying to pare it down to its essence, just a little bit technical and a lot of conclusion. The conclusions can be confirmed or disputed in the discussion threads, and rewrites edited into the original post. That way we can have a top level reference that puts all our discussions together. I need to do this for my own understanding, and I hope it will be useful to others as well :) |
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Fatboyslim  Posts:0
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| 10/13/2004 8:19 PM |
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| [quote:9d7b74caff="Scott"]First, the n-6/n-3 fatty-acid profile of free-range animals is much more favorable compared to feed-lot beef (less than 3.0) The polyunsaturated-saturated ratio is about 1.0 (not high in SFA at all), brains are high in DHA, and marrow is close to 50% mufa.
Cordain L, et al "Fatty acid analysis of wild ruminant tissues: evolutionary implications for reducing diet-related chronic disease" Eur J Clin Nutr 2002 Mar;56(3):181-91
Second, the amount of time humans have spent on the midwest plains is a drop in the bucket compared to the time it took for the human brain to evolve.
[/quote:9d7b74caff]
Well, Scott, heart disease and cancer showed up in force mid 1900's, so how long it took the human brain to develop isn't germane. Your n6/n3 info is right on, and pretty much explains better what I was saying. btw, I've also read the brain is now about 10% smaller than when at it's largest.
On the second part: It's also been said fishing was only learned, what, 40,000 years ago? We were on the plains by then! :) That, too, is a drop in the time bucket. Was scavenging going to account for enough n-3? What are other means of getting it? What are other sources?
Dennis, I think that's a really good idea. A little good clean arguing is just what the board needs!!! :twisted: |
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Scott  Posts:0
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| 10/13/2004 9:33 PM |
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| [quote:cb6a6a4405="Fatboyslim"]
Well, Scott, heart disease and cancer showed up in force mid 1900's, so how long it took the human brain to develop isn't germane. Your n6/n3 info is right on, and pretty much explains better what I was saying. btw, I've also read the brain is now about 10% smaller than when at it's largest.[/quote:cb6a6a4405]
You seemed to be arguing against the consumption of fish (PUFA), and more beef (SFA) and used the midwest plains as an example. I was arguing that a) grass-fed game is low in SFA, b) its higher in n-3 and c) the fact that there was no fish on the great plains is not evidence against omega-3s because it tells you nothing about the conditions that were needed for H. Sapiens to arrive on the scene.
[quote:cb6a6a4405]
On the second part: It's also been said fishing was only learned, what, 40,000 years ago? We were on the plains by then! :) That, too, is a drop in the time bucket. Was scavenging going to account for enough n-3? What are other means of getting it? What are other sources?[/quote:cb6a6a4405]
I could be wrong, but current thinking is that humans crossed the Bering strait about 14,000 years ago. The development of the H Sapien brain (as well as the physiology to go with it) was ongoing for miliions of years, reaching its peak 150,000-200,000 years ago in Africa when H. Sapiens emerged and began to spread out. The development of the brain without a corresponding increase in body mass is believed to be from a shift in the quality of the food source 2 million years ago--scavenging shellfish and freshwater fish, and probably snails, oysters, sea bird eggs--all rich in omega-3s. The lipid ratios of these food resemble the composition of the brain more than any other food. We've been degenerating ever since (especially since the birth of argiculture), but this also means that such degeneration was also occurring when humans roamed the plains within the last 10,000 years, though not nearly as fast because of the greater reliance on wild foods. |
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Fatboyslim  Posts:0
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| 10/14/2004 12:46 AM |
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| [quote:31ad465295="Scott"]You seemed to be arguing against the consumption of fish (PUFA), and more beef (SFA) and used the midwest plains as an example. I was arguing that a) grass-fed game is low in SFA, b) its higher in n-3 and c) the fact that there was no fish on the great plains is not evidence against omega-3s because it tells you nothing about the conditions that were needed for H. Sapiens to arrive on the scene. [/quote:31ad465295] I was trying to argue that it had nothing to do with fish vs. beef, but rather n-6 vs. n-3. Or, to be short, vegetable oils and man-made food items. That is when the diseases of the heart and cancer really got going. But as you said, it all really started with the advent of agriculture. |
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Scott  Posts:0
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| 10/14/2004 4:03 AM |
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| [quote:8ebf58505d="Fatboyslim"] I was trying to argue that it had nothing to do with fish vs. beef, but rather n-6 vs. n-3. Or, to be short, vegetable oils and man-made food items. That is when the diseases of the heart and cancer really got going. But as you said, it all really started with the advent of agriculture.[/quote:8ebf58505d]
Thanks for clarifying. |
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Scott  Posts:0
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| 10/14/2004 4:04 AM |
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| [quote:4f0e1fbabf="gofish"] I need to do this for my own understanding, and I hope it will be useful to others as well :)[/quote:4f0e1fbabf]
I look foward to what you come up with. |
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Fatboyslim  Posts:0
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| 10/14/2004 2:41 PM |
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| Scott, now that I've clarified what I meant, let me muddy it up and be more precise about what I meant. It is n-6(vegetable oils) vs. n-3, but SFA and cholesterol are the fall guys, and got the bum rap as being the problem. That's where I think we got the bum steer. |
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Scott  Posts:0
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| 10/14/2004 3:58 PM |
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| [quote:27fe39c24e="Fatboyslim"]Scott, now that I've clarified what I meant, let me muddy it up and be more precise about what I meant. It is n-6(vegetable oils) vs. n-3, but SFA and cholesterol are the fall guys, and got the bum rap as being the problem. That's where I think we got the bum steer.[/quote:27fe39c24e]
I would agree with that. |
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ActiveForums 3.6
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Dr. Barry Sears is a leading authority on the dietary control of hormonal response. A former research scientist at the Boston University School of Medicine and the Massachusetts Institute of Technology, Dr. Sears has dedicated his research efforts over the past 30 years to the study of lipids. He holds 13 U.S. Patents in the areas of intravenous drug delivery systems and hormonal regulation for the treatment of cardiovascular disease.
A turning point in his research occurred in 1982. That year, the Nobel Prize in Medicine was awarded for discoveries of the role that specialized hormones, known as eicosanoids, play in the development of cardiovascular disease, diabetes, auto-immune diseases, and cancer. Since eicosanoids are only generated from dietary fat, Dr. Sears reasoned that one could apply intravenous drug delivery principles to nutrition in order to control these exceptionally powerful hormonal responses with laser-like precision. In essence, his approach treats food as if it were a drug.
This area of his research led to various patents in the area of hormonal control by essentially using food as an oral drug delivery system to modulate eicosanoids especially for cardiovascular, diabetic, and neurological patients.
The impact of Dr. Sears’ revolutionary work in the dietary control of hormonal response began with the publication of his landmark book, The Zone. Since its publication in June 1995, The Zone has sold more than 2,000,000 hardcover copies, and became a #1 best seller on the New York Times book list. In addition, The Zone has been translated into 22 languages indicating a worldwide response to Dr. Sears’ research. His second book, Mastering the Zone, published in 1997, also became a New York Times bestseller with hardcover sales in excess of 500,000 copies to date. His third book, Zone Perfect Meals in Minutes, published in 1997, quickly became one of the best-selling cookbooks of 1997 and an another New York Times bestseller. The Anti-Aging Zone was published in 1999 and provides the molecular insights into how the Zone Diet can reverse the aging process. The Omega Rx Zone, published in 2002, explores the molecular foundation of chronic disease and how high-dose fish oil can dramatically reverse it. His latest book The Anti-Inflammation Zone discusses how to combat silent inflammation in order to reduce the risk of cancer, heart disease, diabetes, dementia, and many other inflammatory conditions—and how to reverse these conditions if they are already present. To date more than 5 million hardcover copies of his Zone books have been sold in the United States.
His research has elevated food from more than simply a source of calories to being recognized as an exceptionally powerful drug. Because of his revolutionary research, Dr. Sears has been a frequent guest on many national programs such as 20/20, Today, Good Morning America, CBS Morning News, CNN, and MSNBC.
Dr. Sears continues his ongoing research as President of Zone Labs, a biotechnology company in Danvers, MA as well as the President of the non-profit Inflammation Research Foundation in Marblehead, MA. In addition to continuing research on the hormonal effects of food, Dr. Sears has expanded his research in developing innovative dietary approaches to treating cancer and neurological conditions, as well as his on-going work in treating cardiovascular diease and type 2 diabetes.
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I have been taking the Fish Oil for over 3 years now. I am 44 playing hockey and working out. The Fish oil helps with the pain that I get from playing hockey. It greatly enhances my performance on the ice and while working out. I have noticed a big difference in my energy, attentiveness and memory. If I miss a day for whatever reason, I notice a huge difference and it feels like something is missing. Anyway that is my short little story and it comes from the heart.
– Carter B.
I am a nutritionist and Ph.D. doctor of health and nutrition. For Dr. Sears to figure out balancing fat, carbs and protein, is really beyond brilliant. It is a milestone in diet history. I go over people's diet/emotional journals. Mostly all the time, we discover that the fatigue, irritability, unstable emotions were due to the imbalance in their diet. Using the Zone to balance them out, helps control weight, roller coaster emotions and gives them energy. Dr. Sears is so right when he says food is medicine. He has figured out the most powerful drug combination going, called The Zone.
Best and healthy wishes,
– Elaine W., Ph.D., N.C., M.A.
I have a very exhausting job as a flight attendant. I read the "Omega Rx Zone" about 4 years ago and started taking the fish oil. I am 47 and have been flying for 22 years. I am very active, I run and lift weights. But combining lack of regular sleep, a physically demanding job, and irregular eating patterns this job takes a toll on the body. Since taking the fish oil, I have noticed that I do not get exhausted. I get tired, but not exhausted. I stopped taking it for a couple of months and then started taking another company's fish oil. I started getting exhausted again. I came back to Zone Labs and will continue with the fish oil for the rest of my life. I believe in the product and it makes a huge difference in my life. It makes a difference with my running as well. I also bring the bars and shakes with me on the road. It is almost impossible to eat the way I should at work. I haven't found the right secret. At least I have my Zone fish oil, bars, and shakes.
– Kathryn S.
I have been in the Zone, for about 1 month now. I wanted to share with you how wonderful I think this program is. I have been a personal trainer for almost 10 years and actively compete in numerous athletic activities. The Zone program has helped me to achieve a better awareness of my nutritional needs and the results I have seen are amazing! I have lost nearly 13 lbs since I have been in the Zone. I feel more mentally alert, more focused at work, have greater intensity during my training, have made significant strength gains, and just feel better over all. With that said, I would like to thank you for helping me in my quest for "super-health"!
Thank you!
– Rob Y.
I read 'The Zone' and as exactly as I could followed the advice for diet. I noted weight loss progress. Over six months, I lost 33 pounds. One year has passed since then. I have maintained the new weight, guided always by Zone concepts. The Zone is powerful - I have found it fantastic and I am very grateful to Dr Sears.
– Lyn S.
Before I stumbled across the Zone I was weighing close to two hundred pounds and I was depressed. I used to be a gymnast as a young man. I would think, "look at me now," when I looked in a mirror. The day I found 'The Zone' book, I was intrigued and as I read it the science made sense and so, I began to follow the "treatment". I began to lose weight and I was feeling way more energetic. I am forty two years old, I am very active and my weight is down to 162 lbs, 38 pounds lost on the Zone. I cycle, walk, jog, swim and I can now perform some of the more simple gymnastic skills I did twenty years ago...I literally feel like I have turned back the clock.
Thank you!
– Jack J.
I have been on the Zone diet for 7 years. I did not go on the diet to lose weight necessarily; but fairly quickly I lost 25 pounds, going from 190 to 165; from a 36-inch waist to a 32-inch waist. I primarily did the Zone to live healthier. My health is excellent now. I just turned 62 years old. My Zone is my eating lifestyle now; I seldom stray; and I do not miss anything. It is The Good Life.
– Curtis Y.
My wife's doctor told her to read "Enter the Zone" and to do the diet, so I told her I would do it with her. After only one week on the plan we went on a strenuous hike (the first of the year), and when we stopped at our favorite coffee shop on the way home I was able to get out of the car and stand upright and walk into the place without pain or stiffness. The Zone had eliminated all the inflammation that had always forced me to stumble all humped over into the coffee shop any time we skied or hiked all day.
Thank you, Doctor Sears.
– Larry C.
I used to have a lot of knee pain when I walked or ran. I have been taking Omega Rx for almost a year now, and rarely have any pain. I believe it is the anti-inflammation action of the oil. I feel smarter as well. Thanks for developing such a superior oil!
– Joe W.
Prior to following the Zone Diet, my body fat was around 15% and my weight around 153 pounds. No matter what I did, my weight and body fat did not change much. I regularly cycled 20-30 hours per week logging well over 400 miles. That had little impact on body fat or weight. Diet also seemed to have little impact on body fat or weight. Within a couple of months of following the zone diet, my weight dropped rather quickly to 142 pounds and body fat to about 8%. I still regularly cycle up to 20 hours per week (during the summer). I have also started strength training. I eat about 16 blocks per day. I take 3.6 grams of fish oil per day, along with Vitamin E, Alpha Lipoic Acid, CoQ10, and B & C vitamins. I also take GLA, which in my opinion, has significantly reduced fatigue and improved recovery times after exercise.
– Jeremy S.
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All polyphenols have antioxidant properties than can be measured by their Oxygen Radical Absorption Capacity (ORAC), but not all polyphenols have anti-inflammatory properties. The polyphenols in Dr. Sears’ Zone Polyphenol Plus have been carefully chosen to have both.
Polyphenols are the phytochemicals that not only give fruits and vegetables their color, but also help regulate inflammation. In addition, polyphenols also activate the key enzyme (AMP kinase) that helps restore cellular ATP levels. Polyphenols also help regulate the activation of inducible inflammatory proteins (such as COX-2 and inflammatory cytokines).
There are more than 4,000 known polyphenols, and the richest sources are fruits and vegetables. In general, the more color a fruit or vegetable has, the richer the polyphenol content.
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Zone Labs’ Ultra Refined Omega-3 Concentrates are three times fresher and contain less than 1/10th the mercury than what is allowed by the Norwegian Medicinal Standard and European Pharmacopoeia Standard
Zone Labs adheres to the International Fish Oil Standard (IFOS), an independent third party validated laboratory quality standard that is more rigid than any other global standard for purity.
- No company in the worlds runs more tests with IFOS than Zone Labs
- Zone Labs receives a 5 out of 5 star IFOS rating for every batch it tests
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| Standard |
IFOS Standard for a 5-Star Ranking |
Council for Responsible Nutrition |
European Pharmacopeia |
Norwegian Medicinal Standards |
| Peroxide |
< 3.75 meg/kg |
5 meg/kg |
10 meg/kg |
10 meg/kg |
| Totox Levels |
< 20 meg/kg |
26 meg/kg |
NA |
NA |
| Lead |
< 10 ppb |
10 ppb |
100 ppb |
100 ppb |
| Mercury |
< 10 ppb |
10 ppb |
100 ppb |
100 ppb |
| Dioxans and Furans |
< 1 ppt |
2 ppt |
2 ppt |
2 ppt |
| PCBs |
< 45 ppb |
90 ppb |
NA |
NA |
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"IFOS – THE TOP GLOBAL PURITY STANDARD FOR OMEGA-3 FROM FISH"
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Zone Labs products show no detectable lead or mercury when tested down to 10ppb, which is 10 times below the Norwegian Medicinal Standard and European Pharmacopoeia Standard limits.
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Zone Labs products are three times fresher than the minimum allowed by the Norwegian Medicinal Standard and European Pharmacopoeia Standards (based on average peroxide values).
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Zone Labs starts with only wild, small fish from pristine Chilean waters and ends with proprietary validation and testing processes to achieve an IFOS certified 5 star rating.
8-Step Manufacturing Process - Quality Assured
Testing to specification all raw materials, bulk products, packaging material and finished products – always using stringent internal standards and in-process testing.
- Extraction of fish oil
- Winterization – remove limited amounts of saturated fats
- Absorption – remove heavy metals
- Preliminary Molecular Distillation – refining “touch up” to reduce contaminants
- Oil conversion to ethyl esters
- Ethyl ester thermal fractionation – remove additional saturated fats
- True Molecular Distillation – final refining to remove pcb’s and long-chain monoenes
- Rigid Processes – proprietary validation, inspection and encapsulation methods. Independent lab verification of IFOS requirements and certified 5 star rating
No farmed fish. No large fish. Pristine waters.
Zone Labs starts with wild sardines & anchovies fished from cold, pristine waters off of South America where there are less environmental impurities.
A recommended serving of Zone Labs Ultra-Refined Concentrates delivers 8 times more omega-3’s than a typical retail fish oil supplement.
Most fish oil supplements have 30% or less of the healthy omega-3s EPA and DHA, with the remaining 70% of the capsule containing unbeneficial, lesser refined fatty acids that contribute to their bad taste and gastric side effects.
Getting a clinically valid dose of omega-3’s is easy with Zone Labs’ Ultra-Refined Omega-3 Concentrates.
Typical Retail Dose = 300mg omega-3
Standard Zone Dose = 2400mg omega-3
A serving of canned tuna has 12 times less omega-3’s than
Zone Labs Ultra-Refined Omega-3 Concentrates
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Commonly consumed fish and shellfish in the United States
Mercury Source: Food and Drug Administration, FDA 1900-2004, “National Marine Fisheries Service Survey of Trace Elements in the Fishery Resource". Omega-3 Level Source: American Heart Association Website.
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Mercury level
in parts per million (ppm) |
Omega-3 fatty acids
(milligrams per 3-oz. serving) |
| Zone Omega-3 Products |
< 0.01 |
2400 (standard 4 capsule serving |
| Salmon (fresh, frozen) |
0.014 |
1200 |
| Flounder or sole |
0.050 |
480 |
| Pollock |
0.041 |
450 |
| Crab |
0.060 |
400 |
| Scallops |
0.050 |
290 |
| Shrimp |
ND* |
290 |
| Catfish |
0.050 |
270 |
| Clams |
ND* |
250 |
| Cod |
0.095 |
210 |
| Canned Tuna (light) |
0.120 |
200 |
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Zone Labs’ leading product. OmegaRx delivers all of the benefits of Zone Labs’ ultra-refined omega-3 concentrates.
Advantages
- Delivers clinically proven health benefits from the omega-3 fatty acids EPA and DHA*
- Promotes a healthy heart, healthy brain, healthy immune system, healthy circulatory system, healthy joints, healthy moods, healthy triglyceride levels and a healthy pregnancy*
- Combats silent inflammation
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