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Forums > Zone Living Forums > Zone Philosophy
Subject: Specific study?

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matchupeabody User is Offline
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07/08/2004 11:18 PM Alert 
What is (are) the study(ies) that prove insulin activates delta-5 desaturase? Using pubmed.com and going through Dr. Sears’ bibliographies, I come across some studies that link glucagon to suppressing delta-5 desaturase (e.g. Brenner RR, “Nutrition and hormonal factors influencing desaturation…), but not insulin activating it, and others that show insulin even depresses delta-5 desaturase activity (de Gomez Dumm Im, “Effect of insulin on the oxidative…; 1985; Acta Physiol Pharmacol Latinoam). Any zoner out there know the specific study Dr. Sears found when he made "a trip to the bowels of the MIT library" which demonstrated that insulin activates delta 5-desaturase?
Scott User is Offline
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07/09/2004 4:05 AM Alert 
[quote:1fbed33c03="matchupeabody"]What is (are) the study(ies) that prove insulin activates delta-5 desaturase? Using pubmed.com and going through Dr. Sears’ bibliographies, I come across some studies that link glucagon to suppressing delta-5 desaturase (e.g. Brenner RR, “Nutrition and hormonal factors influencing desaturation…), but not insulin activating it, and others that show insulin even depresses delta-5 desaturase activity (de Gomez Dumm Im, “Effect of insulin on the oxidative…; 1985; Acta Physiol Pharmacol Latinoam). Any zoner out there know the specific study Dr. Sears found when he made "a trip to the bowels of the MIT library" which demonstrated that insulin activates delta 5-desaturase?[/quote:1fbed33c03] For the activation of delta-5-desaturase by insulin, please see: Brenner RR "Hormonal modulation of delta-6 and delta-5 desaturases: case of diabetes" Prostaglandins, Leukotrienes and Essential Fatty Acids, Vol. 68, Issue2, Feb 2003 p151-162 el Boustani S, et al "Direct in vivo characterization of delta-5-desaturase activity in humans by deuterium labeling:effect of insulin" Metabolism 1989 Apr;38(4):315-21 Medeiros LC, et al "Insulin, but not estrogen, correlated with indexes of desaturase function in obese women" Horm Metab Res 1995 May;(27);5:235-8
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