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Sue K  Posts:8670
 Zone Expert

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| 02/28/2008 8:12 AM |
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Hi, Has anyone read the current Zone Monday article on DrSears.com? It's very interesting. Here's the address: http://www.drsears.com/tabid/399/itemid/10834/Can-polyphenols-cause-fat-loss.aspx |
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sue
Lost 100 lbs 14 yrs ago, off BP meds, thanks to the Zone diet and Zone fish oil!
To view my before/after pics and meal photos scroll over this picture and click when the link appears.
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janet  Posts:861
 Zoner
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| 03/02/2008 12:56 PM |
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| no but I am interested in polyphenols....exactly which ones quell inflammation....and does spirulina work in this way? |
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Sue K  Posts:8670
 Zone Expert

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| 03/03/2008 12:38 PM |
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Hi janet,
I'm not informed about spirulina to the extent that I can explain what does, though I think it is an algae which contains P, C, and F.
As I understand, there are thousands of polyphenols. They are what gives fruit and veggies their variety of bright colors. There's a test that measures a food's ability to quench free racdicals, the ORAC (oxygen radical absorbing capacity). The deeper colored fruits and veggies contain the higher ORAC levels. Other unexpected foods with high ORAC levels are green tea, and some herbs, like rosemary. The following quote is from a discussion of the ORAC in "the Anti-Inflammamation Zone. "Perhaps the most surprising is that the highest ORAC value belongs to hydroxytyrosol, the Polyphenol found in extra-virgin olive oil. This helps explain why extra-virgin olive oil is so healthful - not only is it an anti-inflammatory agent; it also contains the most powerful antioxidant known."
Here's some more info about polyphenols, taken from the ployphenol page of this site (for more info, click on the "Polyphenol" tab at the top of this page):
"Polyphenols are the phytochemicals that not only give fruits and vegetables their color, but also provide powerful health benefits resulting from their anti-inflammatory and anti-oxidative actions. In addition, polyphenols also activate the key enzyme (AMP kinase) that helps restore cellular ATP levels. This is why fruits and vegetables are the cornerstone of the Zone Diet. The Zone Diet is primarily composed of carbohydrates consisting of fruits and vegetables. At high enough levels, these polyphenols can exert an anti-inflammatory effect by inhibiting the activation of inducible inflammatory proteins (such as COX-2 and inflammatory cytokines) that normally occurs once the innate immune system has been activated" |
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sue
Lost 100 lbs 14 yrs ago, off BP meds, thanks to the Zone diet and Zone fish oil!
To view my before/after pics and meal photos scroll over this picture and click when the link appears.
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snickers  Posts:82
 Aspiring
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| 03/03/2008 6:47 PM |
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I haven't read that article, but I see that Sears has a new supplement that can be taken, which contains anti-inflammatory polyphenols. I am concerned about getting caught in the "hype", and suddenly we all have to take a pill to get our polyphenols, and we all have to take a pill to get this, and that, and.....you can see where this is going. What ever happened to getting what we need from the foods that we eat?1? Sears himself says that food is our medicine, so why is he creating all of these supplements? |
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snickers  Posts:82
 Aspiring
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| 03/03/2008 6:52 PM |
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Ok, I read the article... It really doesn't say much. I am more curious to read the article that he talks about being published, which will hopefully give us more information. |
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Cranberrycat  Posts:5313
 Zone Expert

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| 03/04/2008 11:05 AM |
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I read the article, and it really didn't say much, either. I think that the upcoming article from the Journal of Agricultural and Food Chemistry will be more detailed. The first paragraph of Sear's article suggested that the extracts from the blueberries and strawberries caused fat loss in rats, but that eating the actual blueberries and strawberries would not because of the higher GL (even considering that these food products are fairly low in GL). The second paragraph was a bit more telling, but it is still unclear as to what he is saying. Do we have to EAT the veggies to get the polyphenols, and is the insulin stimulation from the carb going to override the effect of the fat loss, like it does in the berries? Or, will he be directing us to take another supplement, so that we get the extract without the added carb? I am in agreement with CPK's statement that I am NOT in favor of taking another supplement. We human beings survived without supplements all of these years, and there must be a way to get what we need from our food without having to take extra supplements. Fish oil aside, obviously, because I understand the reasoning behind that (pollution that we humans have caused). So, I am anticipating more discussion on this as the article comes out. Hope Sears posts a link to it. |
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Cranberrycat
We don't own the earth; we borrow it from our children.
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janet  Posts:861
 Zoner
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| 03/04/2008 7:13 PM |
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| well I called the zone helpline to ask about the polyphenols...to find out what was in the pill and they read off a long list of the usual suspects, like all the berries, brocolli sprouts, broccoli extract, lycopene from tomato, bilberry, and many more.....resveratrol, etc. I didn't write them down....list too long... |
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Sue K  Posts:8670
 Zone Expert

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| 03/05/2008 10:22 AM |
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| The parts of the short article that I find interesting are the info about polyphenols activating AMP kinase, and leading to increased ATP production, and the mention of the relationship of polyphenols to lower liklihood of type 2 diabetes in individuals who eat more fruits and veggies. |
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sue
Lost 100 lbs 14 yrs ago, off BP meds, thanks to the Zone diet and Zone fish oil!
To view my before/after pics and meal photos scroll over this picture and click when the link appears.
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Cranberrycat  Posts:5313
 Zone Expert

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| 03/05/2008 12:12 PM |
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Yes, but if the intake of the foods that are highest in these polyphenols happens to INCREASE insulin levels (as suggested in the first paragraph), then just how would we manage to LOWER the likelihood of type 2 diabetes? |
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Cranberrycat
We don't own the earth; we borrow it from our children.
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janet  Posts:861
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| 03/05/2008 1:25 PM |
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| I am not knocking it...there is where the pill comes in. it sounds good, but .....another pill? |
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Cranberrycat  Posts:5313
 Zone Expert

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| 03/05/2008 2:53 PM |
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Janet, that is exactly my point! I am not in favor of taking more pills, more supplements. I should be able to get the nutrition that I need from the foods that I eat. |
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Cranberrycat
We don't own the earth; we borrow it from our children.
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Sue K  Posts:8670
 Zone Expert

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| 03/05/2008 4:34 PM |
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[quote]Posted By Cranberrycat on 03/05/2008 12:12 PM Yes, but if the intake of the foods that are highest in these polyphenols happens to INCREASE insulin levels (as suggested in the first paragraph), then just how would we manage to LOWER the likelihood of type 2 diabetes? [/quote] That was specualtion on Barry's part about the rats' insulin. As to your qn "then just how would we manage to LOWER the likelihood of type 2 diabetes?" Lucky for us we're humans and we have the ability to wisely choose an abundance of colorful veggies and fruits and balance them with P and F (the Zone diet). According to the article, just possibly, the polyphenols in all those veggies and fruits we eat with the Zone diet might actually be aiding our ability to lose stored fat, as well as lowering our incidence of type 2 diabetes. |
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sue
Lost 100 lbs 14 yrs ago, off BP meds, thanks to the Zone diet and Zone fish oil!
To view my before/after pics and meal photos scroll over this picture and click when the link appears.
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Cranberrycat  Posts:5313
 Zone Expert

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| 03/05/2008 9:17 PM |
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| Well, I hope that is the case, and that this article doesn't lead to yet another supplement! |
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Cranberrycat
We don't own the earth; we borrow it from our children.
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John  Posts:331
 Zoner

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| 03/06/2008 11:27 AM |
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[quote]Posted By Cranberrycat on 03/05/2008 9:17 PM Well, I hope that is the case, and that this article doesn't lead to yet another supplement! [/quote] You could try some concentrated pomegranate juice. 1 TBL of concentrate is 9g Carb and packed with nutrition. ORAC of Pomegranate is extremely high, if I remember correctly. |
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~john <>< <>< <>< <>< <>< ><> ><> ><> ><> ><>
 <>< <>< <>< PTL Col 3:23-24 ><> ><> ><> |
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Cranberrycat  Posts:5313
 Zone Expert

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| 03/06/2008 4:37 PM |
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| John, that is a good idea, but pomegranete juice is an unfavorable carb, which doesn't work well for me. |
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Cranberrycat
We don't own the earth; we borrow it from our children.
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Sue K  Posts:8670
 Zone Expert

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| 03/06/2008 4:56 PM |
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I drink a little splash of pomegranate juice in a glass of carbonated water a few times a day without elevating my insulin levels. It makes the water a nice red color, more fun to drink, hehe. I'm a very carb sensitive. I can't usually handle eating much fruit, other than berries, w/o feeling hypoglycemic symptoms later, but spreading out a little pomegranate juice like this works fine for me. My fasting insulin has consistently remained around 5 for many yrs. I also eat Sea Health Plus on a daily basis. In addition to the minerals and polyphenols it contains, it aids in fish oil absorption. |
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sue
Lost 100 lbs 14 yrs ago, off BP meds, thanks to the Zone diet and Zone fish oil!
To view my before/after pics and meal photos scroll over this picture and click when the link appears.
 |
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Cranberrycat  Posts:5313
 Zone Expert

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| 03/06/2008 11:41 PM |
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| A splash of pomegranete juice a few times per day is a lot different than consuming an entire block of it. Besides, it is a very expensive juice to have around. |
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Cranberrycat
We don't own the earth; we borrow it from our children.
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Sue K  Posts:8670
 Zone Expert

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| 03/07/2008 6:49 AM |
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Hi Everyone, A 16 oz bottle of the juice I use contains 80 grams of carbohydrate, costs less than $4, and lasts a little over 2 weeks when used in the manner I described. That would put the cost at less than 24 cents a day. |
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sue
Lost 100 lbs 14 yrs ago, off BP meds, thanks to the Zone diet and Zone fish oil!
To view my before/after pics and meal photos scroll over this picture and click when the link appears.
 |
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Cranberrycat  Posts:5313
 Zone Expert

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| 03/07/2008 9:05 AM |
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Sue, I think you are comparing apples to oranges! My post about the pomegranete juice was in response to John's post, and it appears as if he uses much more of it in order to get the polyphenol benefit. You are only using a splash, and I would be more interested in knowing exactly how much of a benefit you are getting, vs. eating blueberries, which IMO would provide a higher amount of polyphenols (and at least it is a favorable source). So, if that didn't make sense, the question is: will a "splash" of pomegranete juice provide equally the same amount (or more) of polyphenol as a block of blueberries? |
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Cranberrycat
We don't own the earth; we borrow it from our children.
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Cranberrycat  Posts:5313
 Zone Expert

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| 03/07/2008 9:07 AM |
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I will have to do some math here... Sue, if you are using 16 oz a little over 2 weeks, then you are using an equivalent of a 1/2 block, based on the figures you posted. John is using one tablespoon, which he is counting as 9 grams of carb. I haven't checked this out, but isn't a tablespoon equal to an ounce? Anyway, I guess the point is that the math isn't jiving. Unless, John's pomegranete juice is more concentrated than Sue's. |
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Cranberrycat
We don't own the earth; we borrow it from our children.
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ActiveForums 3.6
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Dr. Barry Sears is a leading authority on the dietary control of hormonal response. A former research scientist at the Boston University School of Medicine and the Massachusetts Institute of Technology, Dr. Sears has dedicated his research efforts over the past 30 years to the study of lipids. He holds 13 U.S. Patents in the areas of intravenous drug delivery systems and hormonal regulation for the treatment of cardiovascular disease.
A turning point in his research occurred in 1982. That year, the Nobel Prize in Medicine was awarded for discoveries of the role that specialized hormones, known as eicosanoids, play in the development of cardiovascular disease, diabetes, auto-immune diseases, and cancer. Since eicosanoids are only generated from dietary fat, Dr. Sears reasoned that one could apply intravenous drug delivery principles to nutrition in order to control these exceptionally powerful hormonal responses with laser-like precision. In essence, his approach treats food as if it were a drug.
This area of his research led to various patents in the area of hormonal control by essentially using food as an oral drug delivery system to modulate eicosanoids especially for cardiovascular, diabetic, and neurological patients.
The impact of Dr. Sears’ revolutionary work in the dietary control of hormonal response began with the publication of his landmark book, The Zone. Since its publication in June 1995, The Zone has sold more than 2,000,000 hardcover copies, and became a #1 best seller on the New York Times book list. In addition, The Zone has been translated into 22 languages indicating a worldwide response to Dr. Sears’ research. His second book, Mastering the Zone, published in 1997, also became a New York Times bestseller with hardcover sales in excess of 500,000 copies to date. His third book, Zone Perfect Meals in Minutes, published in 1997, quickly became one of the best-selling cookbooks of 1997 and an another New York Times bestseller. The Anti-Aging Zone was published in 1999 and provides the molecular insights into how the Zone Diet can reverse the aging process. The Omega Rx Zone, published in 2002, explores the molecular foundation of chronic disease and how high-dose fish oil can dramatically reverse it. His latest book The Anti-Inflammation Zone discusses how to combat silent inflammation in order to reduce the risk of cancer, heart disease, diabetes, dementia, and many other inflammatory conditions—and how to reverse these conditions if they are already present. To date more than 5 million hardcover copies of his Zone books have been sold in the United States.
His research has elevated food from more than simply a source of calories to being recognized as an exceptionally powerful drug. Because of his revolutionary research, Dr. Sears has been a frequent guest on many national programs such as 20/20, Today, Good Morning America, CBS Morning News, CNN, and MSNBC.
Dr. Sears continues his ongoing research as President of Zone Labs, a biotechnology company in Danvers, MA as well as the President of the non-profit Inflammation Research Foundation in Marblehead, MA. In addition to continuing research on the hormonal effects of food, Dr. Sears has expanded his research in developing innovative dietary approaches to treating cancer and neurological conditions, as well as his on-going work in treating cardiovascular diease and type 2 diabetes.
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I have been taking the Fish Oil for over 3 years now. I am 44 playing hockey and working out. The Fish oil helps with the pain that I get from playing hockey. It greatly enhances my performance on the ice and while working out. I have noticed a big difference in my energy, attentiveness and memory. If I miss a day for whatever reason, I notice a huge difference and it feels like something is missing. Anyway that is my short little story and it comes from the heart.
– Carter B.
I am a nutritionist and Ph.D. doctor of health and nutrition. For Dr. Sears to figure out balancing fat, carbs and protein, is really beyond brilliant. It is a milestone in diet history. I go over people's diet/emotional journals. Mostly all the time, we discover that the fatigue, irritability, unstable emotions were due to the imbalance in their diet. Using the Zone to balance them out, helps control weight, roller coaster emotions and gives them energy. Dr. Sears is so right when he says food is medicine. He has figured out the most powerful drug combination going, called The Zone.
Best and healthy wishes,
– Elaine W., Ph.D., N.C., M.A.
I have a very exhausting job as a flight attendant. I read the "Omega Rx Zone" about 4 years ago and started taking the fish oil. I am 47 and have been flying for 22 years. I am very active, I run and lift weights. But combining lack of regular sleep, a physically demanding job, and irregular eating patterns this job takes a toll on the body. Since taking the fish oil, I have noticed that I do not get exhausted. I get tired, but not exhausted. I stopped taking it for a couple of months and then started taking another company's fish oil. I started getting exhausted again. I came back to Zone Labs and will continue with the fish oil for the rest of my life. I believe in the product and it makes a huge difference in my life. It makes a difference with my running as well. I also bring the bars and shakes with me on the road. It is almost impossible to eat the way I should at work. I haven't found the right secret. At least I have my Zone fish oil, bars, and shakes.
– Kathryn S.
I have been in the Zone, for about 1 month now. I wanted to share with you how wonderful I think this program is. I have been a personal trainer for almost 10 years and actively compete in numerous athletic activities. The Zone program has helped me to achieve a better awareness of my nutritional needs and the results I have seen are amazing! I have lost nearly 13 lbs since I have been in the Zone. I feel more mentally alert, more focused at work, have greater intensity during my training, have made significant strength gains, and just feel better over all. With that said, I would like to thank you for helping me in my quest for "super-health"!
Thank you!
– Rob Y.
I read 'The Zone' and as exactly as I could followed the advice for diet. I noted weight loss progress. Over six months, I lost 33 pounds. One year has passed since then. I have maintained the new weight, guided always by Zone concepts. The Zone is powerful - I have found it fantastic and I am very grateful to Dr Sears.
– Lyn S.
Before I stumbled across the Zone I was weighing close to two hundred pounds and I was depressed. I used to be a gymnast as a young man. I would think, "look at me now," when I looked in a mirror. The day I found 'The Zone' book, I was intrigued and as I read it the science made sense and so, I began to follow the "treatment". I began to lose weight and I was feeling way more energetic. I am forty two years old, I am very active and my weight is down to 162 lbs, 38 pounds lost on the Zone. I cycle, walk, jog, swim and I can now perform some of the more simple gymnastic skills I did twenty years ago...I literally feel like I have turned back the clock.
Thank you!
– Jack J.
I have been on the Zone diet for 7 years. I did not go on the diet to lose weight necessarily; but fairly quickly I lost 25 pounds, going from 190 to 165; from a 36-inch waist to a 32-inch waist. I primarily did the Zone to live healthier. My health is excellent now. I just turned 62 years old. My Zone is my eating lifestyle now; I seldom stray; and I do not miss anything. It is The Good Life.
– Curtis Y.
My wife's doctor told her to read "Enter the Zone" and to do the diet, so I told her I would do it with her. After only one week on the plan we went on a strenuous hike (the first of the year), and when we stopped at our favorite coffee shop on the way home I was able to get out of the car and stand upright and walk into the place without pain or stiffness. The Zone had eliminated all the inflammation that had always forced me to stumble all humped over into the coffee shop any time we skied or hiked all day.
Thank you, Doctor Sears.
– Larry C.
I used to have a lot of knee pain when I walked or ran. I have been taking Omega Rx for almost a year now, and rarely have any pain. I believe it is the anti-inflammation action of the oil. I feel smarter as well. Thanks for developing such a superior oil!
– Joe W.
Prior to following the Zone Diet, my body fat was around 15% and my weight around 153 pounds. No matter what I did, my weight and body fat did not change much. I regularly cycled 20-30 hours per week logging well over 400 miles. That had little impact on body fat or weight. Diet also seemed to have little impact on body fat or weight. Within a couple of months of following the zone diet, my weight dropped rather quickly to 142 pounds and body fat to about 8%. I still regularly cycle up to 20 hours per week (during the summer). I have also started strength training. I eat about 16 blocks per day. I take 3.6 grams of fish oil per day, along with Vitamin E, Alpha Lipoic Acid, CoQ10, and B & C vitamins. I also take GLA, which in my opinion, has significantly reduced fatigue and improved recovery times after exercise.
– Jeremy S.
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All polyphenols have antioxidant properties than can be measured by their Oxygen Radical Absorption Capacity (ORAC), but not all polyphenols have anti-inflammatory properties. The polyphenols in Dr. Sears’ Zone Polyphenol Plus have been carefully chosen to have both.
Polyphenols are the phytochemicals that not only give fruits and vegetables their color, but also help regulate inflammation. In addition, polyphenols also activate the key enzyme (AMP kinase) that helps restore cellular ATP levels. Polyphenols also help regulate the activation of inducible inflammatory proteins (such as COX-2 and inflammatory cytokines).
There are more than 4,000 known polyphenols, and the richest sources are fruits and vegetables. In general, the more color a fruit or vegetable has, the richer the polyphenol content.
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Zone Labs’ Ultra Refined Omega-3 Concentrates are three times fresher and contain less than 1/10th the mercury than what is allowed by the Norwegian Medicinal Standard and European Pharmacopoeia Standard
Zone Labs adheres to the International Fish Oil Standard (IFOS), an independent third party validated laboratory quality standard that is more rigid than any other global standard for purity.
- No company in the worlds runs more tests with IFOS than Zone Labs
- Zone Labs receives a 5 out of 5 star IFOS rating for every batch it tests
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| Standard |
IFOS Standard for a 5-Star Ranking |
Council for Responsible Nutrition |
European Pharmacopeia |
Norwegian Medicinal Standards |
| Peroxide |
< 3.75 meg/kg |
5 meg/kg |
10 meg/kg |
10 meg/kg |
| Totox Levels |
< 20 meg/kg |
26 meg/kg |
NA |
NA |
| Lead |
< 10 ppb |
10 ppb |
100 ppb |
100 ppb |
| Mercury |
< 10 ppb |
10 ppb |
100 ppb |
100 ppb |
| Dioxans and Furans |
< 1 ppt |
2 ppt |
2 ppt |
2 ppt |
| PCBs |
< 45 ppb |
90 ppb |
NA |
NA |
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"IFOS – THE TOP GLOBAL PURITY STANDARD FOR OMEGA-3 FROM FISH"
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Zone Labs products show no detectable lead or mercury when tested down to 10ppb, which is 10 times below the Norwegian Medicinal Standard and European Pharmacopoeia Standard limits.
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Zone Labs products are three times fresher than the minimum allowed by the Norwegian Medicinal Standard and European Pharmacopoeia Standards (based on average peroxide values).
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Zone Labs starts with only wild, small fish from pristine Chilean waters and ends with proprietary validation and testing processes to achieve an IFOS certified 5 star rating.
8-Step Manufacturing Process - Quality Assured
Testing to specification all raw materials, bulk products, packaging material and finished products – always using stringent internal standards and in-process testing.
- Extraction of fish oil
- Winterization – remove limited amounts of saturated fats
- Absorption – remove heavy metals
- Preliminary Molecular Distillation – refining “touch up” to reduce contaminants
- Oil conversion to ethyl esters
- Ethyl ester thermal fractionation – remove additional saturated fats
- True Molecular Distillation – final refining to remove pcb’s and long-chain monoenes
- Rigid Processes – proprietary validation, inspection and encapsulation methods. Independent lab verification of IFOS requirements and certified 5 star rating
No farmed fish. No large fish. Pristine waters.
Zone Labs starts with wild sardines & anchovies fished from cold, pristine waters off of South America where there are less environmental impurities.
A recommended serving of Zone Labs Ultra-Refined Concentrates delivers 8 times more omega-3’s than a typical retail fish oil supplement.
Most fish oil supplements have 30% or less of the healthy omega-3s EPA and DHA, with the remaining 70% of the capsule containing unbeneficial, lesser refined fatty acids that contribute to their bad taste and gastric side effects.
Getting a clinically valid dose of omega-3’s is easy with Zone Labs’ Ultra-Refined Omega-3 Concentrates.
Typical Retail Dose = 300mg omega-3
Standard Zone Dose = 2400mg omega-3
A serving of canned tuna has 12 times less omega-3’s than
Zone Labs Ultra-Refined Omega-3 Concentrates
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Commonly consumed fish and shellfish in the United States
Mercury Source: Food and Drug Administration, FDA 1900-2004, “National Marine Fisheries Service Survey of Trace Elements in the Fishery Resource". Omega-3 Level Source: American Heart Association Website.
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Mercury level
in parts per million (ppm) |
Omega-3 fatty acids
(milligrams per 3-oz. serving) |
| Zone Omega-3 Products |
< 0.01 |
2400 (standard 4 capsule serving |
| Salmon (fresh, frozen) |
0.014 |
1200 |
| Flounder or sole |
0.050 |
480 |
| Pollock |
0.041 |
450 |
| Crab |
0.060 |
400 |
| Scallops |
0.050 |
290 |
| Shrimp |
ND* |
290 |
| Catfish |
0.050 |
270 |
| Clams |
ND* |
250 |
| Cod |
0.095 |
210 |
| Canned Tuna (light) |
0.120 |
200 |
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Zone Labs’ leading product. OmegaRx delivers all of the benefits of Zone Labs’ ultra-refined omega-3 concentrates.
Advantages
- Delivers clinically proven health benefits from the omega-3 fatty acids EPA and DHA*
- Promotes a healthy heart, healthy brain, healthy immune system, healthy circulatory system, healthy joints, healthy moods, healthy triglyceride levels and a healthy pregnancy*
- Combats silent inflammation
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